Antibody-Mediated Insulin Resistance: When Insulin and Insulin Receptor Act as Autoantigens in Humans

Autor: Emmanuel Disse, Christelle Liminet, Karim Chikh, Julien Vouillarmet
Přispěvatelé: Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospices Civils de Lyon (HCL), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Blood Glucose
Male
autoantibodies
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Autoimmunity
insulinoresistance grave
030204 cardiovascular system & hematology
medicine.disease_cause
Autoantigens
Autoantigens/*metabolism
0302 clinical medicine
Endocrinology
severe insulin resistance
80 and over
Chronic
Insulin Resistance/*immunology
Aged
80 and over
Leukemia
biology
General Medicine
Lymphocytic
3. Good health
auto-anticorps
Antibody
medicine.medical_specialty
insulin
030209 endocrinology & metabolism
Lymphocytic lymphoma
03 medical and health sciences
Insulin resistance
Diabetes mellitus
Internal medicine
Internal Medicine
medicine
Diabetes Mellitus
Humans
insuline
Aged
business.industry
Insulin
B-Cell/complications/*immunology/metabolism
Autoantibody
medicine.disease
Leukemia
Lymphocytic
Chronic
B-Cell
Diabetes Mellitus/*immunology/metabolism
Insulin receptor
auto-immunite
Immunology
biology.protein
Insulin Resistance
business
Zdroj: Canadian Journal of Diabetes
Canadian Journal of Diabetes, Canadian Diabetes Association, 2016, 40 (5), pp.462-465. ⟨10.1016/j.jcjd.2016.02.007⟩
ISSN: 1499-2671
DOI: 10.1016/j.jcjd.2016.02.007⟩
Popis: International audience; We report the case of a patient with diabetes presenting a severe insulin-resistance syndrome due to the production of insulin autoantibodies by a lymphocytic lymphoma. We describe the various mechanisms leading to the production of insulin autoantibodies and insulin receptor autoantibodies and review the therapeutic possibilities.
Databáze: OpenAIRE
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