Role of dopamine D3 receptor in alleviating behavioural deficits in animal models of post-traumatic stress disorder
| Autor: | Ying Guo, Dake Song, Rui Song, Chao Shang, Tai-Yun Zhao, Li Yunfeng, Yaping Ge, Zhao-Di Chen, Ning Wu, Jin Li |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.drug_class Anxiety behavioral disciplines and activities Anxiolytic Piperazines Rats Sprague-Dawley Stress Disorders Post-Traumatic 03 medical and health sciences 0302 clinical medicine Dopamine receptor D3 Dopamine mental disorders Medicine Animals Freezing Reaction Cataleptic Biological Psychiatry Pharmacology Mice Knockout Benzoxazoles Electroshock business.industry Traumatic stress Receptors Dopamine D3 medicine.disease 030227 psychiatry Blockade Mice Inbred C57BL Disease Models Animal Schizophrenia Autism Dopamine Antagonists medicine.symptom business Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 84 |
| ISSN: | 1878-4216 |
| Popis: | Post-traumatic stress disorder (PTSD) is a complicated psychiatric disorder, which occurs after exposure to a traumatic event. The main clinical manifestation of PTSD includes fear and stress dysregulation. In both animals and humans, dysregulation of dopamine function appears to be related to conditioned fear responses. Previous studies show that the dopamine D3 receptor (D3R) is involved in schizophrenia, autism, and substance use disorders and is related to emotional disorders. However, few studies have investigated the role of the D3R in the pathogenesis and aetiology of PTSD. In the current study, we have reported that D3R knockout (D3R-/-) mice displayed decreased freezing time of contextual fearing and anxiolytic effects following training sessions consisting of exposure to inescapable electric foot-shocks. Similarly, highly selective blockade of D3Rs by YQA14, a novel D3R antagonist, significantly ameliorated freezing and anxiogenic-like behaviours in the single-prolonged stress (SPS) model of PTSD in rats. And more, YQA14 selectively alleviated the symptoms of PTSD in WT mice but not in D3R-/- mice. In summary, this study demonstrates the anti-PTSD effects of blockade or knockout of the D3R, suggesting that the D3R might play an important role in the pathogenesis and aetiology of PTSD, and might be a potential target for the clinical management of PTSD. |
| Databáze: | OpenAIRE |
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