Value of expression of insulin-like growth factor-1 receptor in gastric adenocarcinomas and normal gastric tissues
| Autor: | Ömer Topalak, Uğur Kantar F, Ulukuş Ç, Küpelioğlu A |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty medicine.medical_treatment Receptor expression Biology Adenocarcinoma Receptor IGF Type 1 chemistry.chemical_compound Insulin-like growth factor Stomach Neoplasms medicine Humans Receptor Aged Neoplasm Staging Aged 80 and over Gastroenterology Cancer Middle Aged medicine.disease chemistry Apoptosis Gastric Mucosa Lymphatic Metastasis Cancer cell Immunohistochemistry Female Growth inhibition Neoplasm Grading |
| Popis: | Background/Aims: Insulin-like growth factor-1 receptor (IGF-1R) plays critical roles in cell proliferation, differentiation, apoptosis, and transformation. Suppression of IGF-1R by means of antisense methods and specific antibodies causes cell apoptosis and growth inhibition of cancer cells. The present study aims to investigate whether there is a difference between normal and cancerous tissue with respect to IGF-1R expression and to assess the relationship between IGF-1R expression and tumor stage, degree of differentiation, and lymph node metastasis by examining IGF-1R expression in cancerous and normal tissues of gastric adenocarcinoma cases of different stages. Materials and Methods: By using immunohistochemical methods, IGF-1Rb (H-60) (1/100, Santa Cruz Biotechnology, SC-9038, Texas,USA) expression was investigated in paraffin-embedded blocks obtained from total/partial gastrectomy material pertaining to 47 gastric adenocarcinoma cases. IGF-1R expression was evaluated semi-quantitatively in terms of intensity and distribution in both normal and cancerous tissues. Results: Insulin-like growth factor-1 receptor expression mean score was 5.38 and 8.40 for cancerous and for normal gastric tissues, respectively. IGF-1R expression decreased significantly in cancerous tissues compared normal tissue (p:0.001). When all cases with and without lymph node metastasis were analyzed, IGF-1R expression was observed to decrease for cases with lymph node metastasis compared to those without lymph node metastasis (p:0.035). Conclusion: Insulin-like growth factor-1 receptor expression in gastric cancer tissue has proven to be considerably lower than IGF-1R expression in normal gastric mucosa. Metastatic progression reduces IGF-1R expression gradually in cancer tissue. |
| Databáze: | OpenAIRE |
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