Guiding dengue vaccine development using knowledge gained from the success of the yellow fever vaccine
| Autor: | Xia Jin, Huabin Liang, Min Lee |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
viruses Immunology Yellow fever vaccine Dengue Vaccines Review Viral Nonstructural Proteins Biology Dengue virus Antibodies Viral Virus Replication medicine.disease_cause Virus Dengue fever Dengue 03 medical and health sciences Immunity Yellow Fever medicine Humans Immunology and Allergy Lymphocytes Phylogeny Dengue vaccine Serine Endopeptidases Yellow Fever Vaccine Yellow fever virus diseases Dendritic Cells Dengue Virus biochemical phenomena metabolism and nutrition Japanese encephalitis medicine.disease Virology Immunity Innate 030104 developmental biology Infectious Diseases Host-Pathogen Interactions Cytokines Yellow fever virus RNA Helicases medicine.drug |
| Zdroj: | Cellular & Molecular Immunology. 13:36-46 |
| ISSN: | 2042-0226 1672-7681 |
| DOI: | 10.1038/cmi.2015.76 |
| Popis: | Flaviviruses comprise approximately 70 closely related RNA viruses. These include several mosquito-borne pathogens, such as yellow fever virus (YFV), dengue virus (DENV), and Japanese encephalitis virus (JEV), which can cause significant human diseases and thus are of great medical importance. Vaccines against both YFV and JEV have been used successfully in humans for decades; however, the development of a DENV vaccine has encountered considerable obstacles. Here, we review the protective immune responses elicited by the vaccine against YFV to provide some insights into the development of a protective DENV vaccine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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