Performance of limited sampling strategies for predicting mycophenolic acid area under the curve in thoracic transplant recipients
| Autor: | Robert D. Levy, Andrew Ignaszewski, Nilufar Partovi, Mary H H Ensom, Lillian S L Ting |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pulmonary and Respiratory Medicine
Thorax Graft Rejection Male medicine.medical_specialty Population Urology Biological Availability Mycophenolic acid Sampling Studies Predictive Value of Tests medicine Limited sampling Humans education Aged Transplantation education.field_of_study business.industry Area under the curve Middle Aged Mycophenolic Acid Kidney Transplantation Surgery Predictive value of tests Area Under Curve Heart Transplantation Transplant patient Female Cardiology and Cardiovascular Medicine business Immunosuppressive Agents medicine.drug Lung Transplantation |
| Zdroj: | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 27(3) |
| ISSN: | 1557-3117 |
| Popis: | Background and Methods Eight limited sampling strategies (LSSs) for estimating mycophenolic acid area under the concentration–time curve (4 developed from lung transplant recipients at our center, 4 developed for heart transplant recipients from other research groups) were evaluated in 27 heart or heart–kidney transplant patients. Results The LSSs from our lung transplant patients performed well when applied to the heart transplant population, with percent bias and percent precision within the acceptable limit of ±15%. Conclusions The LSSs developed at our center are robust enough to be applied to both lung and heart transplant populations. Application of LSSs from other research groups yielded less optimal results, reinforcing the need to re-establish or re-validate LSSs for each specific center. |
| Databáze: | OpenAIRE |
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