Effect of Enterosorption on Animal Lifespan
| Autor: | E. V. Shchorbitskaya, S. M. Novikova, S. N. Gorban, Bogatskaya Ln, G. I. Paramonova, Sabko Ve, A. I. Kovtun, V. M. Shaposhnikov, Vladimir V. Frolkis, Kh. K. Muradian, V. G. Nikolaev, V. K. Koltovor, N. P. Adamenko, A. S. Stupina |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Senescence Aging medicine.medical_specialty Longevity Total rna Biology Toxicology Inbred strain Internal medicine Enterosorption Male rats medicine Protein biosynthesis Animals Microsomal enzymes Myocardium Rats Inbred Strains Lipid metabolism General Medicine Lipid Metabolism Rats Endocrinology Liver Charcoal Protein Biosynthesis RNA |
| Zdroj: | Biomaterials, Artificial Cells and Artificial Organs. 17:341-351 |
| ISSN: | 0890-5533 |
| DOI: | 10.3109/10731198909118290 |
| Popis: | Experiments were performed on Wistar male rats, starting from the 28th month of age. The effect of dietary sorbent (non coated nitrogen-containing carbon administered as 10 day courses at 1 month intervals in dosage of 10 ml/kg) on lifespan and a number of biological indices were studied. Enterosorption resulted in the increase of mean and maximal lifespan by 43 and 34% respectively. Analysis of the effect of enterosorption on activity of microsomal enzymes, intensity of total RNA and protein biosynthesis, lipid metabolism, formation of free radicals etc. showed that it produced a positive influence on the functional state of the studied systems and increased the organism's adaptive capacities. Enterosorption was found to delay the rate of onset of age-related structural changes in the organs and tissues. |
| Databáze: | OpenAIRE |
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