Increased adipose tissue secretion of interleukin-6, but not of leptin, plasminogen activator inhibitor-1 or tumour necrosis factor alpha, in Graves' hyperthyroidism
| Autor: | Hans Wahrenberg, Johan Hoffstedt, Anders Wennlund |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Leptin endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Graves' disease Adipose tissue chemistry.chemical_compound Endocrinology Antithyroid Agents Reference Values Internal medicine Plasminogen Activator Inhibitor 1 Humans Medicine Euthyroid Triiodothyronine Interleukin-6 Tumor Necrosis Factor-alpha business.industry Thyroid General Medicine medicine.disease Graves Disease Thyroxine medicine.anatomical_structure Adipose Tissue chemistry Plasminogen activator inhibitor-1 Female business Plasminogen activator |
| Zdroj: | European Journal of Endocrinology. :607-611 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje.0.1460607 |
| Popis: | OBJECTIVE: This study was designed to investigate adipose tissue secretion of interleukin-6 (IL-6), leptin, tumour necrosis factor alpha (TNF-alpha) and plasminogen activator inhibitor-1 (PAI-1) in Graves' hyperthyroidism. DESIGN: We studied 10 patients before and during (after 8 weeks) anti-thyroid treatment for Graves' hyperthyroidism and 16 healthy, euthyroid control subjects. METHODS: Plasma levels of thyroid hormones and serum/plasma levels of IL-6, leptin, TNF-alpha and PAI-1 were analysed. Subcutaneous fat biopsies were taken for subsequent measurement of IL-6, leptin, TNF-alpha and PAI-1 protein secretion. RESULTS: In patients with Graves' disease, the anti-thyroid treatment resulted in significant reductions of plasma thyroxine and triiodothyronine levels. No differences in serum concentration or adipose tissue secretion of leptin or TNF-alpha were observed either before, as compared with during, anti-thyroid treatment, or in comparison with euthyroid controls. In contrast, plasma PAI-1 activity, but not adipose tissue secretion of PAI-1, was increased both in Graves' disease before as compared with during anti-thyroid treatment (P=0.01) and in thyrotoxic patients compared with euthyroid controls (P=0.0001). Finally, adipose secretion of IL-6 was increased both before (8-fold, P=0.001) and during (6-fold, P |
| Databáze: | OpenAIRE |
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