Estimating the risk of aflatoxin-induced liver cancer in Tanzania based on biomarker data
| Autor: | Candida P. Shirima, Emmanuel A. Mpolya, Martin E. Kimanya, Michael N. Routledge, Yun Yun Gong, Chibundu N. Ezekiel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Aflatoxin Epidemiology Healthy Life Years medicine.disease_cause Tanzania Biochemistry Geographical Locations 0302 clinical medicine Aflatoxins Cost of Illness Risk Factors Medicine and Health Sciences Prevalence heterocyclic compounds 030212 general & internal medicine Multidisciplinary biology Liver Diseases Cancer Risk Factors Poisoning Mortality rate Liver Neoplasms Eukaryota food and beverages Health Care Costs Plants Oncology Food Poisoning Experimental Organism Systems Child Preschool Biomarker (medicine) Medicine Female Quality-Adjusted Life Years Liver cancer Research Article medicine.medical_specialty Science 030231 tropical medicine Gastroenterology and Hepatology Research and Analysis Methods 03 medical and health sciences Signs and Symptoms Model Organisms Plant and Algal Models Albumins Environmental health Gastrointestinal Tumors Biomarkers Tumor medicine Humans Grasses Hepatitis B virus business.industry Carcinoma Organisms Cancers and Neoplasms Biology and Life Sciences Proteins Infant Hepatocellular Carcinoma medicine.disease biology.organism_classification Maize Medical Risk Factors People and Places Africa Animal Studies Clinical Medicine Morbidity business Biomarkers |
| Zdroj: | PLoS ONE, Vol 16, Iss 3, p e0247281 (2021) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Evidence about the magnitude of the aflatoxin menace can help policy makers appreciate the importance of the problem and strengthen policies to support aflatoxin mitigation measures. In this study, we estimated aflatoxin-induced liver cancer risk in 2016 for Tanzania and used the information to estimate the health burden due to the aflatoxin exposure in the country. The burden of aflatoxin-induced liver cancer was assessed based on available aflatoxin biomarker data from a previous epidemiology study, hepatitis B virus infection prevalence and population size of Tanzania in 2016. The health burden due to aflatoxin-induced liver cancer was estimated using disability adjusted life years (DALYs). The aflatoxin exposures ranged from 15.0–10,926.0 ng/kg bw/day (median, 105.5 ng/kg bw/day). We estimated that in 2016 there were about 1,480 (2.95 per 100,000 persons) new cases of aflatoxin-induced liver cancer in Tanzania and assumed all of them would die within a year. These morbidity and mortality rates led to a total loss of about 56,247.63 DALYs. These results show, quantitatively, the cases of liver cancer and related deaths that could be avoided, and the healthy life years that could be saved, annually, by strengthening measures to control aflatoxin contamination in Tanzania. |
| Databáze: | OpenAIRE |
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