Effects of 5-HT4-Receptor Agonists, Cisapride, Mosapride Citrate, and Zacopride, on Cardiac Action Potentials in Guinea Pig Isolated Papillary Muscles
| Autor: | Yoshihide Kii, Tsugutaka Ito |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
Agonist medicine.medical_specialty Sympathetic Nervous System medicine.drug_class Morpholines Guinea Pigs Action Potentials In Vitro Techniques Muscle Smooth Vascular 5-HT3 receptor Zacopride Guinea pig Electrocardiography chemistry.chemical_compound Piperidines Internal medicine medicine Animals Papillary muscle Adrenergic alpha-Antagonists Pharmacology Cisapride biology business.industry Heart Cardiac action potential Prazosin Adrenergic alpha-2 Receptor Antagonists Papillary Muscles Bridged Bicyclo Compounds Heterocyclic musculoskeletal system Mosapride Electric Stimulation Serotonin Receptor Agonists Quaternary Ammonium Compounds medicine.anatomical_structure Endocrinology chemistry Benzamides biology.protein Serotonin Antagonists Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents Microelectrodes medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 29:670-675 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-199705000-00016 |
| Popis: | The purpose of this study was to examine the effects of 5-HT4-receptor agonists cisapride, mosapride citrate (mosapride), and zacopride on action potentials (APs) in guinea pig isolated papillary muscles. Cisapride (0.1-3 microM) concentration-relatedly prolonged the duration of APs (APD) without affecting the other AP parameters. Mosapride and its main metabolite M1 (des-4-fluoro-benzyl-mosapride) did not affect APs at 10 microM. Zacopride at 10 microM shortened APD, and the APD-shortening effect was not affect by GR113808 (10 microM), a 5-HT4-receptor antagonist. The cisapride (1 microM)-induced prolongation of APD was not affected by GR113808 (10 microM), ritanserin (10 microM), a 5-HT2A/2C-receptor antagonist, or prazosin (10 microM), an alpha 1-receptor antagonist. The same concentrations of GR113808, ritanserin, and prazosin did not affect APD. Clofilium, a class III antiarrhythmic agent, prolonged APD; the effect was more pronounced at a stimulus frequency of 0.3 Hz than at 2.0 Hz. Cisapride did not exert such reverse use dependence, suggesting that its mechanism of action is different from that of clofilium. These results suggest that cisapride prolongs APD without involvement of 5-HT2, 5-HT4, or alpha 1 receptors. Mosapride is unlikely to induce the prolongation of electrocardiographic QT intervals correlated with the prolongation of APD in isolated ventricular muscles. |
| Databáze: | OpenAIRE |
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