Frontal predominant encephalopathy with early paligraphia as a distinctive signature of CAR T-cell therapy-related neurotoxicity
| Autor: | Pier Luigi Zinzani, Rossella Santoro, Susanna Mondini, Luca Spinardi, Beatrice Casadei, Luca Faccioli, Francesca Rondelli, Francesca Bonifazi, Andrea Stracciari, Marianna Nicodemo, Umberto Pensato, Giulia Amore, Maria Guarino, Roberto D'Angelo, Rita Rinaldi, Pietro Cortelli, Andrea Farolfi, Michele Dicataldo, Susanna Sammali |
|---|---|
| Přispěvatelé: | Pensato U., Amore G., D'Angelo R., Rinaldi R., Nicodemo M., Rondelli F., Mondini S., Santoro R., Sammali S., Farolfi A., Spinardi L., Faccioli L., Casadei B., Dicataldo M., Bonifazi F., Zinzani P., Cortelli P., Stracciari A., Guarino M. |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Neurology Encephalopathy Immunotherapy Adoptive Short Commentary Immune effectors cell-associated neurotoxicity syndrome (ICANS) Refractory Neurotoxicity Syndrome medicine Humans B-cell lymphoma Neuroradiology Anakinra Brain Diseases Receptors Chimeric Antigen business.industry Neurotoxicity Brain Disease medicine.disease CAR-T therapy Chimeric antigen receptor Cytokine release syndrome (CRS) Treatment Outcome Cancer research Neurotoxicity Syndromes Neurology (clinical) business Cytokine storm-associated encephalopathy (CySE) medicine.drug Human |
| Zdroj: | Journal of Neurology |
| Popis: | Chimeric antigen receptor (CAR) T-cell therapy is an emerging highly effective treatment for refractory haematological malignancies. Unfortunately, its therapeutic benefit may be hampered by treatment-related toxicities, including neurotoxicity. Early aggressive treatment is paramount to prevent neurological sequelae, yet it potentially interferes with the anti-cancer action of CAR T-cells. We describe four CAR T-cells infused patients who presented with reiterative writing behaviours, namely paligraphia, as an early manifestation of neurotoxicity, and eventually developed frontal predominant encephalopathy (one mild, three severe). Paligraphia may represent an early, specific, and easily detectable clinical finding of CAR T-cell therapy-related neurotoxicity, potentially informing its management. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|