Environmental enrichment restores neurogenesis and rapid acquisition in aged rats
| Autor: | Brandi K. Ormerod, Jessica M. Pastoriza, Rachel B. Speisman, Jamie E. Severance, Asha Rani, Ashok Kumar, Thomas C. Foster |
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| Rok vydání: | 2013 |
| Předmět: |
Doublecortin Domain Proteins
Male Aging Time Factors Neurogenesis Spatial Behavior Physiology Cell Count Water maze Environment Hippocampal formation Hippocampus Article Glial Fibrillary Acidic Protein medicine Animals Hippocampus (mythology) Antigens Cognitive decline Maze Learning Neurons Analysis of Variance Environmental enrichment General Neuroscience Neuropeptides Age Factors Rats Inbred F344 Rats medicine.anatomical_structure Bromodeoxyuridine Phosphopyruvate Hydratase Proteoglycans Neurology (clinical) Neuron Analysis of variance Cues Geriatrics and Gerontology Psychology Microtubule-Associated Proteins Neuroscience Psychomotor Performance Developmental Biology |
| Zdroj: | Neurobiology of Aging. 34:263-274 |
| ISSN: | 0197-4580 |
| Popis: | Strategies combatting cognitive decline among the growing aging population are vital. We tested whether environmental enrichment could reverse age-impaired rapid spatial search strategy acquisition concomitantly with hippocampal neurogenesis in rats. Young (5–8 months) and aged (20–22 months) male Fischer 344 rats were pair-housed and exposed to environmental enrichment ( n = 7 young, 9 aged) or housed individually ( n = 7 young, 7 aged) for 10 weeks. After 5 weeks, hidden platform trials (5 blocks of 3 trials; 15 m inter-block interval), a probe trial, and then visible platform trials (5 blocks of 3 trials; 15 m inter-block interval) commenced in the water maze. One week after testing, rats were given 5 daily intraperitoneal bromodeoxyuridine (50 mg/kg) injections and perfused 4 weeks later to quantify neurogenesis. Although young rats outperformed aged rats, aged enriched rats outperformed aged individually housed rats on all behavioral measures. Neurogenesis decreased with age but enrichment enhanced new cell survival, regardless of age. The novel correlation between new neuron number and behavioral measures obtained in a rapid water maze task among aged rats, suggests that environmental enrichment increases their ability to rapidly acquire and flexibly use spatial information along with neurogenesis. |
| Databáze: | OpenAIRE |
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