[Studies on attenuation of post-ischemic brain injury by kampo medicines-inhibitory effects of free radical production. II]
| Autor: | Koichiro Tsuchiya, Shuji Fushitani, Kotaro Murakami, Kazuo Minakuchi, Masumitsu Takasugi |
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| Rok vydání: | 1995 |
| Předmět: |
Male
DPPH Kampo Radical Ischemia Pharmaceutical Science Mice Inbred Strains Brain damage Pharmacology Brain Ischemia Brain ischemia chemistry.chemical_compound Mice Medicine Humans Animals Traditional medicine business.industry Superoxide Brain Free Radical Scavengers medicine.disease Cerebrovascular Disorders chemistry Reperfusion Injury Hydroxyl radical Lipid Peroxidation medicine.symptom business Reactive Oxygen Species Drugs Chinese Herbal |
| Zdroj: | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 115(8) |
| ISSN: | 0031-6903 |
| Popis: | In view of the recent investigation, highly reactive oxygen-derived free radicals may play a role in cerebral ischemia and brain damage, free radical scavenging activity of kampo formulations (Oren-gedoku-to, Keishi-bukuryogan, Saiko-ka-ryukostu-borei-to and Daio-botampi-to) and Kampo components (Ityou, Shini, Menamomi, Arinosudama and Denshiti), used for the attenuation of brain damage, was investigated in vitro. The used experimental system was a radical scavenging action against 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide anion radical (O2-.) and hydroxyl radical (OH.) by the electron spin resonance technique at room temperature. All kampo formulations and kampo components showed radical scavenging activity in a concentration-dependent manner. This result indicates that kampo formulations, treated for brain damage, were good radical scavenger that could possibly prevent ischemic complications such as formation of brain damage. The intensity of scavening activity of kampo formulations for three types of radicals were as follows; 1. DPPH: Daio-botampi-to > Saiko-ka-ryukotsu-borei-to = Keishi-bukuryo-gan > Oren-gedokuto, 2. O2-.: Daio-botampi-to = Keishi-bukuryo-gan > Saiko-ka-ryukotsu-borei-to > Oren-gedoku-to, 3. OH.: Daio-botampi-to = Saiko-ka-ryukotsu-borei-to > Keishi-bukuryo-gan = Oren-gedoku-to. Daio-botampi-to indicated the strongest scavenging activity against three types of radicals. Ischemic brain damage is thought to be an "oketsu" syndrome, which is correlated with abnormalities of the microcirculation. Therefore, Daio-botampi-to, which has been used for "oketsu" syndrome, showed superior free-radical scavenging activity. |
| Databáze: | OpenAIRE |
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