Semaphorin II can function as a selective inhibitor of specific synaptic arborizations
| Autor: | Corey S. Goodman, Helen Sink, Alex L. Kolodkin, David Matthes |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
animal structures
Biochemistry Genetics and Molecular Biology(all) Transgene Presynaptic Terminals Anatomy Neurotransmission Biology Synaptic Transmission General Biochemistry Genetics and Molecular Biology Transmembrane protein In vitro Cell biology Animals Genetically Modified Nerve growth factor nervous system Semaphorin In vivo embryonic structures Animals Drosophila Nerve Growth Factors sense organs biological phenomena cell phenomena and immunity Growth cone |
| Zdroj: | Cell. 81:631-639 |
| ISSN: | 0092-8674 |
| Popis: | Previous studies showed that grasshopper semaphorin I, a transmembrane semaphorin, functions in vivo to steer a pair of growth cones, prevent defasciculation, and inhibit branching; and that chick collapsin, a secreted semaphorin, can function in vitro to cause growth cone collapse. Semaphorin 11, a secreted semaphorin in Drosophila, is transiently expressed by a single large muscle during motoneuron outgrowth and synapse formation. To test the in vivo function of semaphorin 11, we created transgenic Drosophila that generate ectopic semaphorin 11 expression by muscles that normally do not express it. The results show that semaphorin II can function in vivo as a selective target-derived signal that inhibits the formation of specific synaptic terminal arbors. |
| Databáze: | OpenAIRE |
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