Association of plasma apolipoprotein CIII, high sensitivity C-reactive protein and tumor necrosis factor-α contributes to the clinical features of coronary heart disease in Li and Han ethnic groups in China

Autor:	Yueli Liu, Lin Chen, Mingqin Lin, Hui Liu, Lihui Ma, Tiansong Wang, Penghuan Chang, Peiqiong Li, Haifeng Lin, Minzeng Sun
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	0301 basic medicine Blood Glucose Male Apolipoprotein B Endocrinology Diabetes and Metabolism Clinical Biochemistry Myocardial Infarction 030204 cardiovascular system & hematology Gastroenterology Coronary artery disease 0302 clinical medicine Endocrinology Ethnicity lcsh:RC620-627 biology Middle Aged lcsh:Nutritional diseases. Deficiency diseases C-Reactive Protein Female ApoCIII Lipidology medicine.medical_specialty China Clinical chemistry Clinical nutrition Association 03 medical and health sciences Internal medicine medicine Humans Angina Stable Angina Unstable Triglycerides Aged Apolipoproteins B Apolipoprotein C-III Unstable angina business.industry Tumor Necrosis Factor-alpha Research Biochemistry (medical) C-reactive protein Cholesterol HDL Cholesterol LDL medicine.disease Atherosclerosis 030104 developmental biology Blood pressure Logistic Models Case-Control Studies TNF-α Hs-CRP biology.protein business
Zdroj:	Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-9 (2018) Lipids in Health and Disease
DOI:	10.1186/s12944-018-0830-5
Popis:	Background Apolipoprotein CIII (apoCIII) is an independent risk for coronary heart disease (CHD). In this study, we investigated the associations among plasma apoCIII, hs-CRP and TNF-α levels and their roles in the clinical features of CHD in the Li and Han ethnic groups in China. Methods A cohort of 474 participants was recruited (238 atherosclerotic patients and 236 healthy controls) from the Li and Han ethnic groups. Blood samples were obtained to evaluate apoCIII, TNF-α, hs-CRP and lipid profiles. Chi-squared, t-tests, and Kruskal–Wallis or Wilcoxon–Mann–Whitney tests, Pearson or Spearman correlation tests and multiple unconditional logistic regression were employed to analyze lipid profiles and variations in plasma apoCIII, TNF-α, hs-CRP in subgroups of CHD and their contributions to CHD using SPSS version 20.0 software. Results Compared to healthy participants, unfavorable lipid profiles were identified in CHD patients with enhanced systolic pressure, diastolic pressure, fasting blood sugar (FBS), TG, TC, LDL-C, apoB, Lp(a) (P 0.05). Plasma apoCIII, TNF-α and hs-CRP contributed to the development of CHD (OR = 2.554, 7.252, 6.035, P
Databáze:	OpenAIRE
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