Effects of adrenalectomy on CRH regulation of ACTH release: Adenylate cyclase activity, cyclic AMP-dependent protein kinase activity and ACTH release
| Autor: | G.Jean Kant, Gurpreet S. Dhillon, Marvin A. Oleshansky |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Corticotropin-Releasing Hormone medicine.medical_treatment Down-Regulation Adenylate kinase Corticotropin-releasing hormone chemistry.chemical_compound Adrenocorticotropic Hormone Anterior pituitary Pituitary Gland Anterior Corticosterone Internal medicine Adrenal Glands medicine Animals Humans ACTH receptor Protein kinase A Chemistry Adrenalectomy Rats Inbred Strains Cell Biology Rats medicine.anatomical_structure Endocrinology Female Protein Kinases Cyclase activity hormones hormone substitutes and hormone antagonists Adenylyl Cyclases |
| Zdroj: | Cellular Signalling. 1:295-301 |
| ISSN: | 0898-6568 |
| DOI: | 10.1016/0898-6568(89)90047-8 |
| Popis: | Corticotropin releasing hormone (CRH) stimulation of ACTH release and cyclic AMP-mediated events involved in the control of ACTH release were compared in sham-operated and adrenalectomized rats. CRH-stimulated adenylate cyclase activity was decreased in pituitary homogenates from adrenalectomized animals. CRH-stimulated cyclic AMP accumulation was essentially abolished and CRH-stimulated cyclic AMP-dependent protein kinase (A-kinase) activity was decreased in freshly prepared anterior pituitary cells from adrenalectomized animals. Basal and CRH-stimulated ACTH release was elevated in these cells. Since ACTH release is increased in adrenalectomized rats despite the down regulation of CRH-linked pituitary mechanisms, we speculate that the site of action of disinhibition by corticosterone of ACTH release (or synthesis) following adrenalectomy is distal to the generation of cyclic AMP and/or that non-CRH mediated mechanisms assume a greater role in ACTH regulation following adrenalectomy. |
| Databáze: | OpenAIRE |
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