Release of labile cyclo-oxygenase products of arachidonic acid from kidney by endotoxin
| Autor: | V. Içöz, R. K. Türker, K. Özsan |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Lipopolysaccharides
Male medicine.medical_specialty Thromboxane Prostaglandin Prostacyclin Arachidonic Acids Biology Kidney Cellular and Molecular Neuroscience Thromboxane A2 chemistry.chemical_compound Internal medicine medicine Escherichia coli Pressure Animals Molecular Biology Pharmacology Arachidonic Acid Thromboxanes Cell Biology Epoprostenol Rats medicine.anatomical_structure Endocrinology chemistry Prostaglandin-Endoperoxide Synthases Molecular Medicine Liberation lipids (amino acids peptides and proteins) Arachidonic acid Biological Assay Female Rabbits Cyclo-oxygenase medicine.drug Muscle Contraction |
| Zdroj: | Experientia. 40(8) |
| ISSN: | 0014-4754 |
| Popis: | The possible release of prostaglandin (PG)-like substances was studied in isolated perfused kidneys from intact and from intrarenal endotoxin (Lipopolysaccharide-LPS)-injected rabbits, using the venous outflow superflow superfuse assay organ technique. Injection of LPS into the renal artery of an LPS-pretreated kidney caused a release of thromboxane A2 (TXA2) and prostacyclin (PGI2)-like materials into the venous effluent as verified by the responses of the specific assay organs. No detectable release of these substances was found in the venous outflow of LPS-injected intact kidney. The possible role of labile cyclo-oxygenase products of arachidonic acid in the Shwartzman reaction is discussed. |
| Databáze: | OpenAIRE |
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