Alcohol and oxytocin: Scrutinizing the relationship
| Autor: | Hannah D. Fulenwider, Andrey E. Ryabinin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Cognitive Neuroscience Emotions Alcohol Craving Alcohol use disorder Oxytocin Affect (psychology) Article 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine medicine Humans 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Social Behavior business.industry 05 social sciences medicine.disease Anxiety Disorders Neuropsychology and Physiological Psychology Clinical research chemistry Receptors Oxytocin Anxiety Female medicine.symptom business hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Clinical psychology Social behavior medicine.drug |
| Zdroj: | Neurosci Biobehav Rev |
| ISSN: | 0149-7634 |
| DOI: | 10.1016/j.neubiorev.2021.06.009 |
| Popis: | The initial enthusiasm towards oxytocin (OXT) as a potential treatment for alcohol use disorder has been recently tempered by recognizing existing gaps in literature and the recent appearance of a relatively small number of clinical studies with negative outcomes. On the other hand, several new studies continue to support the OXT system's potential for such treatment. In this review, we thoroughly analyze existing literature assessing both alcohol's effects on the OXT system and OXT's effects on alcohol-related behaviors. Both rodent and clinical research is discussed. We identify areas that have been studied extensively and those that have been undeservingly understudied. OXT's potential effects on tolerance, withdrawal, craving, anxiety and social behaviors, and how these processes ultimately affect alcohol consumption, are critically explored. We conclude that while OXT can affect alcohol consumption in males and females, more comprehensive studies on OXT's effects on alcohol-related tolerance, withdrawal, craving, anxiety and social affiliations in subjects of both sexes and across several levels of analyses are needed. |
| Databáze: | OpenAIRE |
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