Mycoplasma pneumoniae and Chlamydophila pneumoniae: a comparative study in patients with nasal polyposis and healthy controls
| Autor: | Charalambos E. Skoulakis, Zoe Florou, John G. Bizakis, Vassilios A. Lachanas, Efthymia Petinaki, Dimitrios G. Ioannidis |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Mycoplasma pneumoniae medicine.medical_treatment medicine.disease_cause Real-Time Polymerase Chain Reaction Gastroenterology Nasal Polyps Internal medicine Pneumonia Mycoplasma medicine Humans Nasal polyps Sinusitis Chlamydophila Infections Asthma Rhinitis business.industry Incidence Chronic sinusitis General Medicine Functional endoscopic sinus surgery Chlamydophila pneumoniae Middle Aged medicine.disease Septoplasty Real-time polymerase chain reaction Otorhinolaryngology Chronic Disease Female business |
| Zdroj: | The Journal of laryngology and otology. 129(9) |
| ISSN: | 1748-5460 0022-2151 |
| Popis: | Introduction:The role played byMycoplasma pneumoniaeandChlamydophila pneumoniaein the pathogenesis of chronic rhinosinusitis with nasal polyps has been the object of ongoing debate. We used real-time polymerase chain reaction to investigate the prevalence of both microorganisms in the nasal tissue samples of patients and controls.Methods:We extracted DNA from nasal polyp samples obtained during functional endoscopic sinus surgery and the inferior turbinate samples of controls undergoing septoplasty. We used the highly sensitive real-time polymerase chain reaction to detect the presence ofM pneumoniaeandC pneumoniaeDNA.Results:Patients with chronic rhinosinusitis with nasal polyps consisted of 62 individuals (39 men; mean age 51 years); the control group consisted of 24 individuals (13 men; mean age 45 years). All samples from both groups were negative forM pneumoniaeandC pneumoniaeDNA.Conclusion:We have demonstrated that the likelihood ofM pneumoniaeandC pneumoniaeacting as an ongoing inflammatory stimulus in chronic rhinosinusitis with nasal polyps is slim. |
| Databáze: | OpenAIRE |
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