Nickel-Catalyzed Three-Component Cross-Electrophile Coupling of 1,3-Dienes with Aldehydes and Aryl Bromides

Autor:	Ya-Qiong Qi, Shuai Liu, Yan Xu, Yang Li, Tong Su, Hai-Liang Ni, Yuanji Gao, Wenhao Yu, Peng Cao, Ping Hu, Ke-Qing Zhao, Bi-Qin Wang, Bin Chen
Rok vydání:	2022
Předmět:	Bromides Aldehydes Molecular Structure Nickel Organic Chemistry Polyenes Physical and Theoretical Chemistry Biochemistry Catalysis
Zdroj:	Organic Letters. 24:5023-5028
ISSN:	1523-7052 1523-7060
Popis:	We herein report a Ni-catalyzed three-component cross-electrophile coupling of 1,3-dienes with aldehydes and aryl bromides using manganese metal as the reducing agent. This efficient protocol accomplishes dicarbofunctionalization of 1,3-dienes to synthesize diverse structural 1,4-disubstituted homoallylic alcohols by forming two new C-C bonds in one time. Mechanistic study suggests that an allyl-nickel(I) species is involved in the catalytic cycle.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732125aa6a272c311d45406a45ddd194 https://doi.org/10.1021/acs.orglett.2c01648 Zobrazit plný text záznamu