Efficacy of stem cells on bone consolidation of distraction osteogenesis in animal models: a systematic review
| Autor: | Cristina Cunha Villar, Fernanda de Toledo Gonçalves, Carlos Manuel Rubio Morillo, Mariane Cristina Sloniak |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Bone Regeneration medicine.medical_treatment Osteogenesis Distraction Review Controlled studies Mesenchymal Stem Cell Transplantation Bioinformatics 03 medical and health sciences 0302 clinical medicine Bias Osteogenesis Risk Factors Animals Medicine General Materials Science Bone formation Bone regeneration Mesenchymal Stromal Cells business.industry Mesenchymal stem cell Reproducibility of Results Mesenchymal Stem Cells 030206 dentistry Study Characteristics Osteogeneses Distraction lcsh:RK1-715 Treatment Outcome 030104 developmental biology lcsh:Dentistry Models Animal Bone consolidation Distraction osteogenesis Stem cell business |
| Zdroj: | Brazilian Oral Research, Vol 32, Iss 0 (2018) Brazilian Oral Research v.32 2018 Brazilian Oral Research Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO Brazilian Oral Research, Volume: 32, Article number: e83, Published: 14 NOV 2018 |
| ISSN: | 1807-3107 1806-8324 |
| DOI: | 10.1590/1807-3107bor-2018.vol32.0083 |
| Popis: | Distraction osteogenesis (DO) relies on the recruitment and proliferation of mesenchymal stem cells (MSC) to the target site, where they differentiate into osteoblasts to promote bone formation. Nevertheless, MSC recruitment appears to be slow and limits bone formation in DO defects. Thus, this systematic review aims to evaluate the ability of locally applied MSC to enhance bone formation in DO preclinical models. Databases were searched for quantitative pre-clinical controlled studies that evaluated the effect of local administration of MSC on DO bone formation. Eligible studies were identified and data regarding study characteristics, outcome measures and quality were extracted. Nine studies met the inclusion criteria. Autogenous and xenogenous MSC were used to promote DO bone formation. These included bone marrow-derived MSC, adipose tissue-derived MSC and MSC derived from human exfoliated deciduous teeth. Meta-analysis was not possible due to heterogeneities in study designs. Local MSC implantation was not associated with adverse effects. In 4 out of the 5 studies, locally delivered undifferentiated bone-marrow MSC had a positive effect on DO bone formation. Few studies evaluated the therapeutic effects of MSC from other sources. The adjunct use of biologically active molecules or forced expression of key genes involved in osteogenesis further boosted the ability of bone-marrow MSC to promote DO bone formation. While risk of bias and heterogeneity limited the strength of this systematic review, our results suggest that the use of MSC is safe and may provide beneficial effects on DO bone formation. |
| Databáze: | OpenAIRE |
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