Mechanical alteration of blood flow in smoked and unsmoked lung areas after inhalation injury
| Autor: | H. A. Linares, T. Prien, Rifat Tokyay, Lillian D. Traber, H. M. Loick, Daniel L. Traber |
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| Rok vydání: | 1992 |
| Předmět: |
Pulmonary Circulation
Neutrophils Physiology Hemodynamics Lung injury Physiology (medical) medicine Animals Lung Sheep Inhalation business.industry Respiratory disease Lung Injury Left pulmonary artery Smoke Inhalation Injury respiratory system medicine.disease respiratory tract diseases medicine.anatomical_structure Reperfusion Injury Anesthesia Female Lipid Peroxidation business Perfusion Blood Flow Velocity Respiratory tract |
| Zdroj: | Journal of Applied Physiology. 72:1692-1700 |
| ISSN: | 1522-1601 8750-7587 |
| Popis: | The degree of pulmonary perfusion may have an important role in the pathogenesis of inhalation injury. We studied this in sheep that had only one lung exposed to smoke. The right lung and upper airway of 12 chronically instrumented sheep were insufflated with cotton smoke. In six animals, the left pulmonary artery was occluded between 4 and 10 h after smoke insufflation. All animals were studied for 24 h and then killed, and lung tissue was harvested. The smoked as well as the air-insufflated lung of all animals showed an increase in wet-to-dry weight ratio and tissue conjugated dienes (products of lipid peroxidation). Neither the intermittent blood flow increase to the smoked lung nor the simultaneous blood flow reduction with a concomitant polymorphonuclear neutrophil entrapment in the air-insufflated lung significantly affected the histopathological outcome of the respective lung. We conclude that tissue damage after inhalation injury cannot be diminished by increasing the flow to smoked areas. Ischemia-reperfusion injury does not have a major role in the lung damage seen with inhalation injury. |
| Databáze: | OpenAIRE |
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