Serum Concentrations of Penicillin Following Administration of Crystalline Procaine Penicillin G in Aqueous Suspension
| Autor: | Philip Whittlesey, William L. Hewitt |
|---|---|
| Rok vydání: | 1948 |
| Předmět: |
Aqueous solution
Chromatography medicine.drug_class Chemistry Antibiotics Water Penicillin G Procaine Penicillins Benzylpenicillin Aqueous suspension General Biochemistry Genetics and Molecular Biology Penicillin Procaine Blood serum Suspensions Procaine penicillin G polycyclic compounds medicine medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 68:658-661 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-68-16586 |
| Popis: | Summary1. Administration of 300,000 units of crystalline procaine penicillin G in aqueous suspension produced demonstrable serum penicillin concentrations at 12 hours after administration in all subjects and at 24 hours after injection in 92% of subjects studied.2. Administration of 600,000 units of this material produced demonstrable serum penicillin concentrations 24 hours after injection in all subjects.3. Similar patterns of serum penicillin concentrations were obtained for both the oil and the aqueous suspensions of procaine penicillin G although slightly lower values were generally observed with the aqueous suspension.4. Ease of administration and absence of untoward: local or systemic reaction were uniformly observed with the administration of procaine penicillin G in aqueous suspension. |
| Databáze: | OpenAIRE |
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