Effects of Bariatric Surgery on Renal Function in Obese Patients: A Systematic Review and Meta Analysis
| Autor: | Qinggui Ren, Weijie Liu, Xiaodong Han, Kun Li, Hongwei Zhang, Pin Zhang, Jianzhong Di, Jianan Zou, Zhibin Ye |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Physiology 030232 urology & nephrology Bariatric Surgery lcsh:Medicine Pathology and Laboratory Medicine urologic and male genital diseases law.invention 0302 clinical medicine Mathematical and Statistical Techniques Randomized controlled trial law Chronic Kidney Disease Medicine and Health Sciences lcsh:Science Randomized Controlled Trials as Topic Multidisciplinary Inulin Middle Aged female genital diseases and pregnancy complications Proteinuria Observational Studies as Topic Treatment Outcome Physiological Parameters Nephrology Meta-analysis Physical Sciences Female medicine.symptom Glomerular hyperfiltration Statistics (Mathematics) Research Article Glomerular Filtration Rate Adult medicine.medical_specialty Renal function 030209 endocrinology & metabolism Surgical and Invasive Medical Procedures Research and Analysis Methods 03 medical and health sciences Digestive System Procedures Young Adult Signs and Symptoms Diagnostic Medicine medicine Humans Obesity Statistical Methods Renal Physiology business.industry urogenital system Body Weight lcsh:R Biology and Life Sciences medicine.disease Surgery Albuminuria Microalbuminuria Observational study lcsh:Q business Mathematics Kidney disease Meta-Analysis |
| Zdroj: | PLoS ONE, Vol 11, Iss 10, p e0163907 (2016) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background Obesity is an independent risk factor of development and progression of chronic kidney disease (CKD). Data on the benefits of bariatric surgery in obese patients with impaired kidney function have been conflicting. Objective To explore whether there is improvement in glomerular filtration rate (GFR), proteinuria or albuminuria after bariatric surgery. Methods We comprehensively searched the databases of MEDLINE, Embase, web of science and Cochrane for randomized, controlled trials and observational studies that examined bariatric surgery in obese subjects with impaired kidney function. Outcomes included the pre- and post-bariatric surgery GFR, proteinuria and albuminuria. In obese patients with hyperfiltration, we draw conclusions from studies using measured GFR (inulin or iothalamate clearance) unadjusted for BSA only. Study quality was evaluated using the Newcastle-Ottawa Scale. Results 32 observational studies met our inclusion criteria, and 30 studies were included in the meta-analysis. No matter in dichotomous data or in dichotomous data, there were statistically significant reduction in hyperfiltration, albuminuria and proteinuria after bariatric surgery. Limitations The main limitation of this meta-analysis is the lack of randomized controlled trials (RCTs). Another limitation is the lack of long-term follow-up. Conclusions Bariatric surgery could prevent further decline in renal function by reducing proteinuria, albuminuria and improving glomerular hyperfiltration in obese patients with impaired renal function. However, whether bariatric surgery reverses CKD or delays ESRD progression is still in question, large, randomized prospective studies with a longer follow-up are needed. |
| Databáze: | OpenAIRE |
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