Therapeutic efficacy of eprinomectin extended-release injection against induced infections of developing (fourth-stage larvae) and adult nematode parasites of cattle
| Autor: | Soll Mark D, S. Yoon, D.G. Baggott, G.C. Royer, L.G. Cramer, Steffen Rehbein |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Veterinary medicine Efficacy Nematodes Cattle Diseases Injections Subcutaneous injection Random Allocation Helminths Extended-release injection Animals Nematode Infections Larva Eprinomectin Ivermectin General Veterinary biology Trichuris ovis Antinematodal Agents General Medicine biology.organism_classification veterinary(all) Nematode Treatment Outcome Parasitology Trichostrongylus axei Cattle Female Therapy Haemonchus contortus |
| Zdroj: | Veterinary parasitology. 192(4) |
| ISSN: | 1873-2550 |
| Popis: | The therapeutic efficacy of eprinomectin in an extended-release injection (ERI) formulation was evaluated against induced infections of developing fourth-stage larval or adult gastrointestinal and pulmonary nematodes of cattle in a series of six studies under two identical protocols (three each for developing fourth-stage larvae or adults) conducted in the USA, Germany or the UK (two studies at each location, one per stage). Each study initially included 16 nematode-free cattle. The cattle were of various breeds or crosses, weighed 109-186.5 kg prior to treatment, and were approximately 4-7 months old. The animals were blocked based on pre-treatment bodyweight and then randomly allocated to treatment: eprinomectin ERI vehicle (control) at 1 mL/50 kg body weight or eprinomectin 5% ERI at 1 mL/50 kg bodyweight (1.0 mg eprinomectin/kg) for a total of eight and eight animals in each group. Treatments were administered once on Day 0 by subcutaneous injection in front of the shoulder. In each study, cattle were infected with a combination of infective third-stage larvae or eggs of gastrointestinal and pulmonary nematodes. Inoculation was scheduled so that the nematodes were expected to be fourth-stage larvae or adults at the time of treatment. For parasite recovery, all study animals were humanely euthanized and necropsied 14-15 (adult infections) or 21-22 days after treatment (developing fourth-stage larval infections). When compared with the vehicle-treated control counts, efficacy of eprinomectin ERI against developing fourth-stage larvae and adults was ≥98% (p |
| Databáze: | OpenAIRE |
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