Amphiphilic peptoid transporters--synthesis and evaluation
| Autor: | Sidonie B. L. Vollrath, Daniel Fürniss, Ute Schepers, Stefan Bräse |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Dose-Response Relationship
Drug Molecular Structure Peptidomimetic Cell Survival Organic Chemistry Peptoid Transporter Biological Transport Biochemistry Combinatorial chemistry chemistry.chemical_compound Peptoids Structure-Activity Relationship Surface-Active Agents Drug Delivery Systems chemistry Amphiphile Drug delivery Side chain Humans Amine gas treating Click Chemistry Physical and Theoretical Chemistry HeLa Cells |
| Zdroj: | Organicbiomolecular chemistry. 11(47) |
| ISSN: | 1477-0539 |
| Popis: | Cell-penetrating peptoids are an important class of peptidomimetics, which can replace highly biodegradable cell penetrating peptides for enhanced drug delivery. Typically, they contain positively charged amino side chains which are synthesized via their protected analogues. To avoid the use of amine protecting groups a Click-chemistry based modular synthesis of novel hydrophilic as well as amphiphilic cell penetrating peptoids was developed to generate novel structures for drug delivery in cells. |
| Databáze: | OpenAIRE |
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