Parenteral vitamin D supplementation is superior to oral in vitamin D insufficient patients with type 2 diabetes mellitus
| Autor: | Saurabh Singh, Shalbha Tiwari, Balram Gupta, A.K. Dwivedi, Daliparthy D. Pratyush, Surya Kumar Singh |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Administration Oral 030209 endocrinology & metabolism Type 2 diabetes vitamin D deficiency 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine Internal Medicine Vitamin D and neurology medicine Humans Infusions Parenteral 030212 general & internal medicine Vitamin D Gastrointestinal tract Intention-to-treat analysis Vitamin d supplementation business.industry Type 2 Diabetes Mellitus General Medicine Middle Aged Vitamin D Deficiency medicine.disease Endocrinology Diabetes Mellitus Type 2 Female business |
| Zdroj: | Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 11:S373-S375 |
| ISSN: | 1871-4021 |
| DOI: | 10.1016/j.dsx.2017.03.019 |
| Popis: | Background/objectives Oral vitamin D supplementation is better than parenteral in improving vitamin D deficiency in individuals with no systemic illness. Our aim was to compare the efficacy of oral and parenteral routes of vitamin D supplementation on circulating serum 25(OH) vitamin D level in patients with type 2 diabetes mellitus. Methods Total 85 cases of with type 2 diabetes mellitus were screened for vitamin D status of which 71 patients were vitamin D insufficient/deficient. They were randomized into two intent to treat groups with different vitamin D supplementation protocols (a) Oral-60000 IU per day for 5 days (group I; n = 40) and (b) injectable-300000 IU intramuscularly once (group II; n = 31). Baseline and one month post supplementation 25(OH) vitamin D levels were measured in both the groups. Results Baseline clinical characteristics and 25(OH) vitamin D levels were comparable in both the groups. Post treatment 25(OH) vitamin D level in group I was 26.06 ± 9.06 ng/ml and in group II was 49.69 ± 18.92 ng/ml. After one month of vitamin D supplementation, increment in 25(OH) vitamin D level from baseline was significantly higher in group II than group I (p Interpretation & conclusions Injectable method of supplementation was better than oral route in improving serum 25 (OH) vitamin D status in patients with type 2 diabetes. The study suggested impaired absorption of vitamin D from the gastrointestinal tract in patients with type 2 diabetes mellitus and a need for parenteral route of vitamin D supplementation in deficient patients with type 2 diabetes mellitus. |
| Databáze: | OpenAIRE |
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