Erythrocyte membrane fatty acid composition as a marker of dietary compliance in hyperlipidaemic subjects
| Autor: | Ian C. Steele, D. Paul Nicholls, Maria B. Tynan, Raymond Moore, S. Maguire, Cyril McMaster, J. Pearce, Elisabeth R. Trimble |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Dietary compliance Hyperlipidemias Biology Body Mass Index Internal medicine Mole medicine Humans Aged Erythrocyte Membrane Fatty Acids Middle Aged Red cell membrane Compliance (physiology) Erythrocyte membrane Red blood cell Endocrinology medicine.anatomical_structure Patient Compliance Female Fatty acid composition Cardiology and Cardiovascular Medicine Body mass index |
| Zdroj: | Atherosclerosis. 117:245-252 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/0021-9150(95)05578-k |
| Popis: | Dietary intervention is the first treatment step in the management of hyperlipidaemia, but there are few objective criteria of compliance. Whether intensive dietary intervention would produce a detectable change in erythrocyte membrane fatty acid composition which could be used as a marker of compliance was examined in 31 new hyperlipidaemic patients. Over a 6 month period, body mass index fell from 29.0 to 26.9 kg/m2 (P < 0.001) and total cholesterol by 19% from 8.16 to 6.58 mmol/l (P < 0.001). The energy derived from fat was reduced from 38.5% to 29.6% (P < 0.001), and the ratio of dietary polyunsaturated to saturated (P:S) fatty acids in the diet increased from 0.45 to 0.66 (P < 0.01). Small but significant changes were recorded in several red cell membrane fatty acids, and the P:S ratio increased from 0.91 to 1.13 (P < 0.001). It would appear, therefore, that red cell membrane changes parallel dietary changes and hence are a potential marker for compliance with dietary changes. |
| Databáze: | OpenAIRE |
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