Effects of Probiotics on Gut Microbiota in Patients with Inflammatory Bowel Disease: A Double-blind, Placebo-controlled Clinical Trial
| Autor: | Maryam Vaezjalali, Mahdi Shadnoush, L Navai, Ahad Khalilnezhad, Rahebeh Shaker Hosseini, Hossein Goudarzi |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
DNA Bacterial Male medicine.medical_specialty Population Gut flora Placebo Real-Time Polymerase Chain Reaction Gastroenterology Inflammatory bowel disease Group B Feces Double-Blind Method Lactobacillus Internal medicine medicine Bacteroides Humans education Bifidobacterium education.field_of_study biology business.industry Probiotics food and beverages General Medicine Middle Aged biology.organism_classification medicine.disease Inflammatory Bowel Diseases Placebo Effect Gastrointestinal Microbiome Intestines Female business |
| Zdroj: | The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi. 65(4) |
| ISSN: | 2233-6869 |
| Popis: | BACKGROUND/AIMS Several clinical trials have revealed various advantages for probiotics in inflammatory bowel disease (IBD). The aim of this study was to further investigate the effects of probiotic yogurt consumption on gut microbiota in patients with this disease. METHODS A total of 305 participants were divided into three groups; group A (IBD patients receiving probiotic yogurt; n=105), group B (IBD patients receiving placebo; n=105), and control group (healthy individuals receiving probiotic yogurt; n=95). Stool samples were collected both before and after 8 weeks of intervention; and population of Lactobacillus, Bifidobacterium and Bacteroides in the stool specimens was measured by Taqman real-time PCR method. RESULTS By the end of the intervention, no significant variations in the mean weight and body mass index were observed between three groups (p>0.05). However, the mean numbers of Lactobacillus, Bifidobacterium, and Bacteroides in group A were significantly increased compared to group B (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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