Putative Role of Carbon Monoxide Signaling Pathway in Penile Erectile Function
| Autor: | Taymour Mostafa, Hanan Fouad, Laila A. Rashed, Hazem Atta, Dina Sabry, Mohamed A Wassef, Mohamed T. Abdel Aziz |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Urology Endocrinology Diabetes and Metabolism ATPase Calcium-Transporting ATPases Biology Pharmacology Nitric oxide chemistry.chemical_compound Endocrinology Erectile Dysfunction Internal medicine Cyclic GMP-Dependent Protein Kinases medicine Humans Protein kinase A Cyclic guanosine monophosphate Carbon Monoxide Heme oxygenase Psychiatry and Mental health medicine.anatomical_structure Reproductive Medicine chemistry Cavernous tissue Heme Oxygenase (Decyclizing) biology.protein Nitric Oxide Synthase medicine.symptom Signal transduction Vasoconstriction Signal Transduction |
| Zdroj: | The Journal of Sexual Medicine. 6:49-60 |
| ISSN: | 1743-6095 |
| Popis: | Introduction Erectile response depends on nitric oxide (NO) generated by NO synthase (NOS) enzyme of the nerves and vascular endothelium in the cavernous tissue. NO activates soluble guanylate cyclase (sGC), leading to the production of cyclic guanosine monophosphate (cGMP). cGMP activates cGMP-dependent protein kinase that activates Ca 2+ /ATPase pump that activates Ca 2+ /K efflux pump extruding Ca 2+ across the plasma membrane with consequent smooth muscle cell relaxation. A role similar to that of NOS/NO signaling has been postulated for carbon monoxide (CO) produced in mammals from heme catabolism by heme oxygenase (HO) enzyme. Aim To assess CO signaling pathway for erectile function by reviewing published studies. Methods A systematic review of published studies on this affair based on Pubmed and Medical Subject Heading databases, with search for all concerned articles. Main Outcome Measures Documentation of positive as well as negative criteria of CO/HO signaling focused on penile tissue. Results The concept that HO-derived CO could play a role in mediating erectile function acting in synergism with, or as a potentiator for, NOS/NO signaling pathway is gaining momentum. CO/HO signaling pathway has been shown to partially mediate the actions of oral phosphodiesterase type 5 inhibitors. In addition, it was shown that the use of CO releasing molecules potentiated cavernous cGMP levels. However, increased CO production or release was reported to be associated, in some studies, with vasoconstriction. Conclusion This review sheds a light on the significance of cavernous tissue CO signaling pathway that may pave the way for creation of therapeutic modalities based on this pathway. Abdel Aziz MT, Mostafa T, Atta H, Wassef MA, Fouad HH, Rashed LA, and Sabry D. Putative role of carbon monoxide signaling pathway in penile erectile function. |
| Databáze: | OpenAIRE |
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