Central effects of various ligands on drinking behavior in eels acclimated to seawater
| Autor: | Yasuaki Fujii, Tomohiro Kozaka, Masaaki Ando |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Agonist
Serotonin medicine.medical_specialty Physiology medicine.drug_class Acclimatization Peptide Hormones Vasoactive intestinal peptide Drinking Behavior Substance P Aquatic Science Ligands Phenylephrine chemistry.chemical_compound Vasotocin Atrial natriuretic peptide Internal medicine medicine Animals Seawater Molecular Biology gamma-Aminobutyric Acid Ecology Evolution Behavior and Systematics Eels Angiotensin II Isoproterenol Acetylcholine Ghrelin Prolactin Endocrinology chemistry Insect Science Animal Science and Zoology Atrial Natriuretic Factor Vasoactive Intestinal Peptide medicine.drug |
| Zdroj: | Journal of Experimental Biology. 206:687-692 |
| ISSN: | 1477-9145 0022-0949 |
| Popis: | Intracranial injection of eel angiotensin II (eANG II, 5x10(-13)-5x10(-8) mol), acetylcholine (ACh, 5x10(-12)-5x10(-9) mol), substance P (5x10(-10) mol) and isoproterenol (a beta-adrenoceptor agonist, 5x10(-11)-5x10(-9) mol) enhanced water intake in the seawater eel. The effects of eANG II, ACh and isoproterenol were dose-dependent. By contrast, water intake was inhibited by intracranial injection of eel atrial natriuretic peptide (eANP, 5x10(-13)-5x10(-10) mol), serotonin (5-HT, 5x10(-12)-5x10(-8) mol), ghrelin (5x10(-12)-5x10(-10) mol), gamma-amino butyric acid (GABA, 5x10(-11)-5x10(-8) mol), prolactin (PRL, 5x10(-10)-5x10(-9) mol), arginine vasotocin (AVT, 5x10(-12) mol), vasoactive intestinal peptide (VIP, 5x10(-11) mol), noradrenaline (5x10(-9) mol l(-1)) and phenylephrine (alpha-adrenoceptor agonist, 5x10(-11)-5x10(-9) mol). The inhibitory effects of eANP, 5-HT, ghrelin, GABA, PRL and phenylephrine were dose-dependent. The intracranial stimulatory effect of eANG II was relatively long-lasting compared with the intravenous effect. The stimulatory effect of intravenous eANG II disappeared immediately, and was followed by an inhibition, which could be well explained by an increase in eANP secretion from the atrium. |
| Databáze: | OpenAIRE |
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