Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype
| Autor: | Åke Lernmark, Barbro Lernmark, Juan Merlo, S-A Ivarsson, Kristian Lynch, Corrado M. Cilio |
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| Rok vydání: | 2008 |
| Předmět: |
endocrine system
endocrine system diseases Pregnancy in Diabetics medicine.disease_cause Autoimmunity Islets of Langerhans Pregnancy HLA-DQ Antigens Odds Ratio medicine Humans Genetic Predisposition to Disease Receptor-Like Protein Tyrosine Phosphatases Class 8 Pregnancy Complications Infectious Autoantibodies Type 1 diabetes geography geography.geographical_feature_category Glutamate Decarboxylase business.industry Histocompatibility Testing Infant Newborn Autoantibody Obstetrics and Gynecology Environmental Exposure Environmental exposure Fetal Blood medicine.disease Islet Gastroenteritis Cross-Sectional Studies Diabetes Mellitus Type 1 Cord blood Pediatrics Perinatology and Child Health Immunology Gestation Female Seasons business |
| Zdroj: | Journal of Perinatology. 28:211-217 |
| ISSN: | 1476-5543 0743-8346 |
| DOI: | 10.1038/sj.jp.7211912 |
| Popis: | Human leukocyte antigen DQ (HLA-DQ) genetic factors and islet autoantibodies are strongly associated with type 1 diabetes (T1D) and are currently used to predict T1D. This study examined whether islet autoantibodies in the cord blood of newborns to nondiabetic mothers were associated with the (T1D) high-risk genotype HLA-DQ2/8, gestational infections or both. Cord blood samples were taken from 33 683 newborns and used for HLA typing and analyses of islet autoantibodies. Parents completed questionnaires when the child was 2 months of age. The prevalence of newborn islet autoantibodies consistently varied with season over 4 years (P |
| Databáze: | OpenAIRE |
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