Multiple periods of functional ocular dominance plasticity in mouse visual cortex
| Autor: | Patrick O. Kanold, Carla J. Shatz, Marta Majdan, Yoshiaki Tagawa |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
genetic structures
Proline Nerve Tissue Proteins Tetrodotoxin Biology Tritium Brain mapping Eye Enucleation Statistics Nonparametric Ocular dominance Arc (geometry) Mice Cortex (anatomy) medicine Biological neural network Animals Visual Pathways RNA Messenger Anesthetics Local In Situ Hybridization Vision Ocular Visual Cortex Brain Mapping Monocular Neuronal Plasticity General Neuroscience Critical Period Psychological Age Factors eye diseases Dominance Ocular Mice Inbred C57BL Monocular deprivation Cytoskeletal Proteins medicine.anatomical_structure Visual cortex Animals Newborn Gene Expression Regulation Enzyme Induction sense organs Neuroscience Proto-Oncogene Proteins c-fos Photic Stimulation Densitometry |
| Zdroj: | Nature neuroscience. 8(3) |
| ISSN: | 1097-6256 |
| Popis: | The precise period when experience shapes neural circuits in the mouse visual system is unknown. We used Arc induction to monitor the functional pattern of ipsilateral eye representation in cortex during normal development and after visual deprivation. After monocular deprivation during the critical period, Arc induction reflects ocular dominance (OD) shifts within the binocular zone. Arc induction also reports faithfully expected OD shifts in cat. Shifts towards the open eye and weakening of the deprived eye were seen in layer 4 after the critical period ends and also before it begins. These shifts include an unexpected spatial expansion of Arc induction into the monocular zone. However, this plasticity is not present in adult layer 6. Thus, functionally assessed OD can be altered in cortex by ocular imbalances substantially earlier and far later than expected. |
| Databáze: | OpenAIRE |
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