High-resolution studies of lysis–lysogeny decision-making in bacteriophage lambda
| Autor: | Lanying Zeng, Jimmy T. Trinh, Qiuyan Shao |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
030102 biochemistry & molecular biology JBC Reviews Disease progression Gene regulatory network High resolution Context (language use) Cell Biology Computational biology Biology Lambda biology.organism_classification Bacteriophage lambda Biochemistry Bacteriophage 03 medical and health sciences 030104 developmental biology Lytic cycle Lysogenic cycle DNA Viral RNA Viral Lysogeny Molecular Biology |
| Zdroj: | Journal of Biological Chemistry. 294:3343-3349 |
| ISSN: | 0021-9258 |
| DOI: | 10.1074/jbc.tm118.003209 |
| Popis: | Cellular decision-making guides complex development such as cell differentiation and disease progression. Much of our knowledge about decision-making is derived from simple models, such as bacteriophage lambda infection, in which lambda chooses between the vegetative lytic fate and the dormant lysogenic fate. This paradigmatic system is broadly understood but lacking mechanistic details, partly due to limited resolution of past studies. Here, we discuss how modern technologies have enabled high-resolution examination of lambda decision-making to provide new insights and exciting possibilities in studying this classical system. The advent of techniques for labeling specific DNA, RNA, and proteins in cells allows for molecular-level characterization of events in lambda development. These capabilities yield both new answers and new questions regarding how the isolated lambda genetic circuit acts, what biological events transpire among phages in their natural context, and how the synergy of simple phage macromolecules brings about complex behaviors. |
| Databáze: | OpenAIRE |
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