Long-term oncologic results of patients with distal rectal cancer treated by local excision with or without adjuvant treatment
| Autor: | Seung Hyuk Baek, Kang Young Lee, Yong Taek Ko, Chang Hwan Cho, Seung Kook Sohn, Byung Soh Min, Nam Kyu Kim |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Local excision Time Factors Colorectal cancer medicine.medical_treatment Disease-Free Survival Recurrence Internal medicine medicine Carcinoma Humans Aged Aged 80 and over Rectal Neoplasms Abdominoperineal resection business.industry Gastroenterology Middle Aged Hepatology medicine.disease Surgery Radiation therapy Treatment Outcome Adenocarcinoma Female Radiotherapy Adjuvant business Adjuvant |
| Zdroj: | International Journal of Colorectal Disease. 22:1325-1330 |
| ISSN: | 1432-1262 0179-1958 |
| Popis: | The aim of this study is to review long-term oncologic results of local excision (LE) and to investigate the validity and feasibility of LE as a treatment option for distal rectal cancer.Seventy-six patients who underwent LE for distal rectal adenocarcinoma with curative intent from 1991 to 2000 at Severance Hospital Yonsei University Medical Center, Seoul, Korea were enrolled in this study.Preoperative transrectal ultrasonography revealed 3 cases of uT0, 55 cases of uT1 and 18 cases of uT2. Postoperative pathologic examination revealed 10 cases of pT0 (where no residual cancer cells remained), 11 cases of pTis, 37 cases of pT1, 16 cases of pT2, and 2 cases of pT3. Eleven out of 37 patients with pT1 tumors received adjuvant radiation therapy. Among 16 patients with pT2 tumor, 7 undertook salvage operation and 8 received adjuvant therapy. The median follow-up period was 84.9 months. Local recurrence was observed in six patients. The 5-year local recurrence-free survival rate (LFS) was 89.4% in the pT1 group and 75.0% in the pT2 group (p = 0.012). Among the patients with pT1 cancer, those who received adjuvant radiation therapy demonstrated a 5-year LFS of 100%, compared to those who did not, 76.0% (p = 0.038).Our results imply a potential role of LE and adjuvant radiation as an option for the treatment of distal rectal cancer, and that even for pT1 carcinoma, LE alone might not be a valid modality. |
| Databáze: | OpenAIRE |
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