αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family
| Autor: | Lorena A. Ostilla, Cara J. Gottardi, Annette S. Flozak, Sergio E. Chiarella, Erik E. Rabin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Gene isoform Histology Heart Diseases catenins actin Cardiomyopathy Review Disease Biology Biochemistry DNA-binding protein Adherens junction 03 medical and health sciences Hypersensitivity medicine Animals Humans Gene neurological Cadherin Desmosomes Cell Biology asthma medicine.disease Cell biology 030104 developmental biology cell-cell adhesion adherens junctions Catenin Nervous System Diseases signaling cardiomyopathy cadherins alpha Catenin Biology of epithelial barriers |
| Zdroj: | Tissue Barriers |
| ISSN: | 2168-8370 |
| DOI: | 10.1080/21688370.2018.1463896 |
| Popis: | α-Catenins are actin-filament binding proteins and critical subunits of the cadherin-catenin cell-cell adhesive complex. They are found in nominally-defined epithelial (E), neural (N), and testis (T) forms transcribed from three distinct genes. While most of α-catenin research has focused on the developmentally essential founding member, αE-catenin, this review discusses recent studies on αT-catenin (CTNNA3), a developmentally dispensable isoform that is emerging as relevant to cardiac, allergic and neurological diseases. |
| Databáze: | OpenAIRE |
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