Innate receptors for adaptive immunity
| Autor: | Giorgia Rota, Marie Cécile Michallet, Greta Guarda, Kendle M. Maslowski |
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| Přispěvatelé: | Immunité et lymphocytes cytotoxiques – Immunity and cytotoxic lymphocytes, Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Biochemistry [Lausanne], Université de Lausanne (UNIL), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lausanne = University of Lausanne (UNIL) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
Intrinsic immunity animal diseases T-Lymphocytes Antigen presentation Immune receptor Biology Pattern Recognition Adaptive Immunity Microbiology 03 medical and health sciences 0302 clinical medicine Immune system Receptors Innate Animals Humans 030304 developmental biology 0303 health sciences B-Lymphocytes Innate immune system Receptors Pattern Recognition/metabolism Innate lymphoid cell Pattern recognition receptor Immunity B-Lymphocytes/immunology T-Lymphocytes/immunology Acquired immune system [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology Immunity Innate Cell biology Infectious Diseases Receptors Pattern Recognition Immunology [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology [SDV.IMM]Life Sciences [q-bio]/Immunology 030215 immunology |
| Zdroj: | Current Opinion in Microbiology Current Opinion in Microbiology, 2013, 16 (3), pp.296-302. ⟨10.1016/j.mib.2013.04.003⟩ Current opinion in microbiology Scopus-Elsevier |
| DOI: | 10.1016/j.mib.2013.04.003⟩ |
| Popis: | International audience; Pattern recognition receptors (PRRs) are commonly known as sensor proteins crucial for the early detection of microbial or host-derived stress signals by innate immune cells. Interestingly, some PRRs are also expressed and functional in cells of the adaptive immune system. These receptors provide lymphocytes with innate sensing abilities; for example, B cells express Toll-like receptors, which are important for the humoral response. Strikingly, certain other NOD-like receptors are not only highly expressed in adaptive immune cells, but also exert functions related specifically to adaptive immune system pathways, such as regulating antigen presentation. In this review, we will focus particularly on the current understanding of PRR functions intrinsic to B and T lymphocytes; a developing aspect of PRR biology. |
| Databáze: | OpenAIRE |
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