5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment
| Autor: | Kamyar Shameli, Mostafa Yusefi, Michiele Soon Lee-Kiun, Kit-Kim Siew, Wei Ling Lim, Kamil Kuca, Magdelyn Mei-Theng Wong, Sin-Yeang Teow, Hui-Yin Chan, Roshafima Rasit Ali |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Drug
Polymers and Plastics Cell Survival Polymers Colorectal cancer media_common.quotation_subject Antineoplastic Agents Pharmaceutical formulation Nanocomposites chemistry.chemical_compound Drug Delivery Systems Materials Chemistry medicine Humans Cellulose media_common Drug Carriers Nanocomposite Chemistry Magnetic Phenomena Organic Chemistry HCT116 Cells medicine.disease In vitro Drug Liberation Fluorouracil Microscopy Electron Scanning Magnetic Iron Oxide Nanoparticles Nanocarriers Colorectal Neoplasms HT29 Cells Nuclear chemistry medicine.drug |
| Zdroj: | Carbohydrate Polymers. 273:118523 |
| ISSN: | 0144-8617 |
| DOI: | 10.1016/j.carbpol.2021.118523 |
| Popis: | Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-fluorouracil carrier abbreviated as MC/5-FU for potential colorectal cancer treatments. Several analyses indicated the multifunctional properties of MC/5-FU bionanocomposites. Transmission and scanning electron microscopy study demonstrated that Fe3O4 nanofillers covered the cellulose matrix. The drug release from MC/5-FU was evaluated under various pH and temperature conditions, showing the maximum release at pH 7.4 and 44.2 °C. In in vitro anticancer assay, MC/5-FU exhibited enhanced selectivity and anticancer actions against 2D monolayer and 3D tumour spheroid models colorectal cancer cells. The anticancer effects of MC/5-FU with magnetic targeting and heat induction were also examined. This easily synthesized MC/5-FU indicated the potential in application as a low-cost drug formulation for colorectal cancer treatments. |
| Databáze: | OpenAIRE |
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