Prognostic Signifi cance of the Lymph Node Ratio Regarding Recurrence and Survival in Rectal Cancer Patients Treated with Postoperative Chemoradiotherapy
| Autor: | Ji-Yoon Kim, In Kyu Lee, Mi-Ryeong Ryu, Su-Mi Chung, Byung-Ock Choi, Jong-Man Won, Chang-Hyeok An |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Colorectal cancer Lymphovascular invasion medicine.medical_treatment Rectal neoplasms Gastroenterology Capecitabine Internal medicine medicine Stage (cooking) Lymph nodes Lymph node Chemotherapy Alimentary Tract Hepatology business.industry Combined modality therapy medicine.disease Surgery Radiation therapy medicine.anatomical_structure Original Article Lymph business medicine.drug |
| Zdroj: | Gut and Liver |
| ISSN: | 2005-1212 1976-2283 |
| DOI: | 10.5009/gnl.2012.6.2.203 |
| Popis: | Background/Aims To evaluate the prognostic impact of the lymph node ratio (LNR: the ratio of positive lymph nodes to the total number of lymph nodes examined) on disease recurrence and survival among rectal cancer patients who received curative surgery and postoperative chemoradiotherapy (CRT). Methods Between 1995 and 2008, 124 patients with pathologic T3-4 or node-positive rectal cancer underwent curative surgery and postoperative CRT. Postoperative radiotherapy was delivered at a median dose of 50.4 Gy (range, 45 to 59.4 Gy) for 6 weeks. Chemotherapy consisted of a bolus injection of 5-fluorouracil and leucovorin in the first and last week of radiotherapy (91.9%) or daily capecitabine during radiotherapy (8.1%). Further adjuvant chemotherapy was administered after chemoradiation. Results The median follow-up was 5.1 years. In the multivariate analysis, pathologic N (pN) stage and lymphovascular invasion were significantly associated with disease-free survival and disease-specific survival (p0.05). Conclusions The LNR predicts recurrence and survival more accurately than pN stage. The pN stage and the LNR should be considered together when estimating the risk of disease recurrence among rectal cancer patients. |
| Databáze: | OpenAIRE |
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