Mechanisms Underlying the Association of Chronic Obstructive Pulmonary Disease With Heart Failure
| Autor: | Hamish D.C. Bain, John Belcher, Christopher A. Miller, Matthias Schmitt, Jakub Lagan, Daniel Prescott, Joshua Bradley, Jennifer K Quint, Christien Fortune, Erik B. Schelbert, Anthony Ashworth, Robin M Egdell, Foluwakemi Ogunyemi, Mahvash Zaman, Josephine H. Naish, Richard Barraclough, Christopher Wong, Bruce R. Irwin, Edward Hearne, David Clark, Helen Thorpe, Tasneem Bangi, Richard Timoney, Jerome McIntosh, Jørgen Vestbo, Graham Devereux |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
030204 cardiovascular system & hematology Ventricular Function Left 030218 nuclear medicine & medical imaging 03 medical and health sciences Pulmonary Disease Chronic Obstructive 0302 clinical medicine RC705 Interquartile range Predictive Value of Tests Internal medicine medicine Clinical endpoint Humans Radiology Nuclear Medicine and imaging Longitudinal Studies Prospective Studies Heart Failure COPD Proportional hazards model business.industry Hazard ratio Stroke Volume medicine.disease Prognosis RC666 Confidence interval respiratory tract diseases Heart failure Cardiology Myocardial fibrosis Cardiology and Cardiovascular Medicine business |
| ISSN: | 1936-878X |
| Popis: | Objectives The purposes of this study were to determine why chronic obstructive pulmonary disease (COPD) is associated with heart failure (HF). Specific objectives included whether COPD is associated with myocardial fibrosis, whether myocardial fibrosis is associated with hospitalization for HF and death in COPD, and whether COPD and smoking are associated with myocardial inflammation. Background COPD is associated with HF independent of shared risk factors. The underlying pathophysiological mechanism is unknown. Methods A prospective, multicenter, longitudinal cohort study of 572 patients undergoing cardiac magnetic resonance (CMR), including 450 patients with COPD and 122 age- and sex-matched patients with a median: 726 days (interquartile range: 492 to 1,160 days) follow-up. Multivariate analysis was used to examine the relationship between COPD and myocardial fibrosis, measured using cardiac magnetic resonance (CMR). Cox regression analysis was used to examine the relationship between myocardial fibrosis and outcomes; the primary endpoint was composite of hospitalizations for HF or all-cause mortality; secondary endpoints included hospitalizations for HF and all-cause mortality. Fifteen patients with COPD, 15 current smokers, and 15 healthy volunteers underwent evaluation for myocardial inflammation, including ultrasmall superparamagnetic particles of iron oxide CMR. Results COPD was independently associated with myocardial fibrosis (p |
| Databáze: | OpenAIRE |
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