Cutaneous ulceration after injection of polyethylene-glycol-modified interferon alpha associated with visual disturbances in a melanoma patient
| Autor: | Lucie Heinzerling, Günter Burg, Hannes G. H. Wildberger, Reinhard Dummer |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Vision Disorders Alpha interferon Dermatology Polyethylene glycol Interferon alpha-2 Gastroenterology Polyethylene Glycols chemistry.chemical_compound Internal medicine Skin Ulcer medicine Humans Melanoma Interferon alfa Hepatitis business.industry Multiple sclerosis food and beverages Interferon-alpha Middle Aged medicine.disease Recombinant Proteins chemistry Immunology Sarcoma Vasculitis business medicine.drug |
| Zdroj: | Dermatology (Basel, Switzerland). 201(2) |
| ISSN: | 1018-8665 |
| Popis: | Interferons are used in the therapy of multiple sclerosis, Kaposi’s sarcoma, hepatitis and melanoma. Their short half-life that requires frequent injections can be increased by polyethylene glycol (PEG) modification. A 50-year-old patient was diagnosed as having an acrolentiginous melanoma (Breslow >5 mm, Clark level IV) and inguinal lymph node metastases. After surgical excision and lymphadenectomy, immune therapy with 6.0 μg pegylated interferon α2b/kg body weight, s.c., was started. Cutaneous ulcerations at the injection sites developed 9 months after treatment initiation. The patient also developed blurred vision and presented with binasal scotomas and pathological visually evoked potentials and electroretinogram. The cutaneous ulcerations slowly healed under local therapy and reduction of the concentration of the PEG-modified interferon from 0.86 to 0.43 mg/ml. The dosage was maintained. Two months later, the therapy was stopped due to disease progression. Vision subsequently recovered. Cutaneous reactions evolved at the sites of subcutaneous injections of PEG-modified interferon α2b. Changes in vision can probably be attributed to immunotherapy. |
| Databáze: | OpenAIRE |
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