A 2015 outbreak of flea-borne rickettsiosis in San Gabriel Valley, Los Angeles County, California

Autor: Kenn Fujioka, Allen L. Richards, Alice N. Maina, J. Wakoli Wekesa, Curtis Croker, Angela Brisco, Kimberly J. Nelson, Chelsea Foo, Rachel Civen, Van Ngo
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Veterinary medicine
Flea
Physiology
animal diseases
Pathology and Laboratory Medicine
Cat Diseases
Disease Outbreaks
Major Histocompatibility Complex
0302 clinical medicine
Medicine and Health Sciences
Public and Occupational Health
Rickettsia
Mammals
education.field_of_study
biology
lcsh:Public aspects of medicine
Eukaryota
Middle Aged
Antibodies
Bacterial
Los Angeles
3. Good health
Bacterial Pathogens
Body Fluids
Insects
Blood
Infectious Diseases
Fleas
Medical Microbiology
Vertebrates
Siphonaptera
Pathogens
Anatomy
Research Article
Adult
lcsh:Arctic medicine. Tropical medicine
Arthropoda
Infectious Disease Control
lcsh:RC955-962
030231 tropical medicine
030106 microbiology
Population
Immunology
Marsupials
Microbiology
03 medical and health sciences
Flea Infestations
medicine
Animals
Humans
education
Microbial Pathogens
Aged
Bacteria
Public Health
Environmental and Occupational Health
Organisms
Outbreak
Biology and Life Sciences
Rickettsia Infections
lcsh:RA1-1270
Opossums
medicine.disease
biology.organism_classification
bacterial infections and mycoses
Rickettsia felis
Invertebrates
Spotted fever
Insect Vectors
Rickettsiosis
Amniotes
Cats
Clinical Immunology
Clinical Medicine
Typhus
Zdroj: PLoS Neglected Tropical Diseases, Vol 12, Iss 4, p e0006385 (2018)
PLoS Neglected Tropical Diseases
ISSN: 1935-2735
1935-2727
Popis: Although flea-borne rickettsiosis is endemic in Los Angeles County, outbreaks are rare. In the spring of 2015 three human cases of flea-borne rickettsiosis among residents of a mobile home community (MHC) prompted an investigation. Fleas were ubiquitous in common areas due to presence of flea-infested opossums and overabundant outdoor cats and dogs. The MHC was summarily abated in June 2015, and within five months, flea control and removal of animals significantly reduced the flea population. Two additional epidemiologically-linked human cases of flea-borne rickettsiosis detected at the MHC were suspected to have occurred before control efforts began. Molecular testing of 106 individual and 85 pooled cat fleas, blood and ear tissue samples from three opossums and thirteen feral cats using PCR amplification and DNA sequencing detected rickettsial DNA in 18.8% of the fleas. Seventeen percent of these cat fleas tested positive for R. felis-specific DNA compared to under two (
Author summary Outbreaks of flea-borne rickettsiosis are rare despite the endemic status in Los Angeles County. In the spring of 2015 three human cases of flea-borne rickettsiosis among residents of a mobile home community (MHC) prompted an investigation. Fleas were found in all common areas at the MHC due to presence of flea-infested opossums and overabundant outdoor cats and dogs. The MHC was summarily abated in June 2015, and within five months, flea control and removal of animals significantly reduced the flea population. Two additional epidemiologically-linked human cases detected at the MHC were considered to have occurred before control efforts began. Molecular testing of cat fleas, immunological testing of opossums and feral cats collected at the site indicated active transmission of flea-borne rickettsiosis. This study represents the first flea-borne rickettsial outbreak that summary abatement approach was used to reduce its intensity.
Databáze: OpenAIRE
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