A common variant associated with prostate cancer in European and African populations
| Autor: | Olafia S Gretarsdottir, Jelena Kostic, Kari Agnarsson, Carole Ober, Unnur Thorsteinsdottir, James E. Montie, Bjarni A. Agnarsson, Kristleifur Kristjansson, Adalheidur Olafsdottir, Jon Thor Bergthorsson, Daniel F. Gudbjartsson, William J. Catalona, Rosa B. Barkardottir, Jeffrey R. Gulcher, Adam Baker, Katarina Bälter, Margret Jakobsdottir, Jesus Sainz, Gudmundur Geirsson, Helgi J Isaksson, Julius Gudmundsson, Thorarinn Blondal, Kristrun R. Benediktsdottir, Louise le Roux, Gudmar Thorleifsson, Patrick Sulem, Fredrik Wiklund, Jean-Baptiste Cazier, Margret B. Andresdottir, Shyamali Ghosh, Julie A. Douglas, Laufey T. Amundadottir, Kari Stefansson, Kathleen A. Cooney, Arnaldur Gylfason, Andrei Manolescu, Gudmundur V. Einarsson, Droplaug N Magnusdottir, Augustine Kong, Asgeir Sigurdsson, Jan-Erik Johansson, Birgitta Birgisdottir, Agnar Helgason, Henrik Grönberg, Brian K. Suarez, Xiaoying Yu |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
education.field_of_study Incidence (epidemiology) Population Black People Prostatic Neoplasms Disease Odds ratio Biology medicine.disease Polymorphism Single Nucleotide White People Prostate cancer Attributable risk Genetics medicine Humans MSMB Allele education Alleles Microsatellite Repeats Demography |
| Popis: | With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry. |
| Databáze: | OpenAIRE |
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