Molecular Epidemiology of Community-Associated Antimicrobial-ResistantStaphylococcus aureusin Seoul, Korea (2003): Pervasiveness of Multidrug-Resistant SCCmecType II Methicillin-ResistantS. aureus
| Autor: | Kyung Won Seo, Jungeun Lee, Kyungwon Lee, Seung Hee Park, Dong Kwon Rhee, Bo Kyung Choi, Young Lim Kim, Kyoung Min Baek, Hye Yoon Jeong |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Microbiology (medical) Staphylococcus aureus Adolescent Immunology Microbial Sensitivity Tests Drug resistance Biology Staphylococcal infections medicine.disease_cause Polymerase Chain Reaction Microbiology Antibiotic resistance Bacterial Proteins Drug Resistance Multiple Bacterial Prevalence medicine Humans Penicillin-Binding Proteins Child Pharmacology Molecular Epidemiology Korea SCCmec Infant Newborn Infant Clindamycin Sequence Analysis DNA Middle Aged Staphylococcal Infections biochemical phenomena metabolism and nutrition bacterial infections and mycoses medicine.disease Virology Anti-Bacterial Agents Electrophoresis Gel Pulsed-Field Community-Acquired Infections Penicillin Child Preschool Multilocus sequence typing Methicillin Resistance medicine.drug |
| Zdroj: | Microbial Drug Resistance. 13:178-185 |
| ISSN: | 1931-8448 1076-6294 |
| DOI: | 10.1089/mdr.2007.709 |
| Popis: | There is an extremely high incidence of antimicrobial resistance of the clinical isolates of Staphylococcus aureus in Korea. This study carried out a molecular investigation to determine the prevalence of the community-associated antimicrobial-resistant S. aureus and methicillin-resistant S. aureus (MRSA). The percentage resistance from the nasal swabs of healthy volunteers in 2003 in Seoul is as follows: penicillin (91%), erythromycin (EM, 14%), gentamicin (GM, 9.3%), tetracycline (TE, 8.2%), cephalothin (4%), oxacillin (OX, MRSA; 3.8%), clindamycin (CC, 2.6%), ciprofloxacin (CIP, 0.8%), and sulfamethoxazole/trimethoprim (0.6%). The community-associated MRSA (C-MRSA) strains were examined by pulsed-field gel electrophoresis (PFGE) analysis of the SmaI macro-fragments, multilocus sequence typing (MLST), and staphylococcal cassette chromosome mec (SCCmec) typing using the PCR analysis. The Korean C-MRSA isolates were clustered into three distinct groups. One PFGE group containing the C-MRSA strains showed resistance to CC, EM, and GM, a high level (32-96 microg/ml) of resistance to methicillin, sequence type 5 (ST5), and SCCmec type II, which is the most common hospital associated-MRSA (H-MRSA) isolated in Korea. These results highlight the heterogeneous genetic background of the C-MRSA as well as the pervasiveness of the H-MRSA isolates in this community. |
| Databáze: | OpenAIRE |
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