Direct Measurement of the Anti-Influenza Agent Zanamivir in the Respiratory Tract following Inhalation
| Autor: | Stefano Milleri, Daniel S. Stein, Amy W. Peng |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty viruses Respiratory System Neuraminidase Antiviral Agents Guanidines Gastroenterology Zanamivir Internal medicine Administration Inhalation medicine Viral neuraminidase Humans Pharmacology (medical) Respiratory system Pyrans Pharmacology biology Inhalation business.industry Sputum Nasal Lavage Fluid Orthomyxoviridae respiratory tract diseases Infectious Diseases medicine.anatomical_structure Immunology Sialic Acids biology.protein Female medicine.symptom business Respiratory tract medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 44:1974-1976 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.44.7.1974-1976.2000 |
| Popis: | In a single-center, randomized study, zanamivir (Relenza) concentrations in induced sputum samples and nasal washings of healthy adults following oral inhalation were measured. Concentrations in sputum exceeded the median viral neuraminidase 50% inhibitory concentration at 6, 12, and 24 h, and those in nasal washings did so at 6 and 12 h. There were no zanamivir-related adverse events or laboratory abnormalities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|