Cross-sectional and longitudinal investigation of human herpesvirus 8 seroprevalence in HIV-1-infected individuals in Osaka, Japan
| Autor: | Dai Watanabe, Yudai Yamamoto, Yasuharu Nishida, Kazuyuki Hirota, Misa Ashida, Daisuke Kasai, Takuma Shirasaka, Takashi Ueji, Sachiko Suzuki, Motoko Ikuma, Tomoko Uehira, Satomi Yukawa, Erina Matsumoto |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Male medicine.medical_specialty viruses Population Enzyme-Linked Immunosorbent Assay HIV Infections Antibodies Viral Virus Men who have sex with men 03 medical and health sciences 0302 clinical medicine Japan Blood product Seroepidemiologic Studies Internal medicine medicine Seroprevalence Humans Pharmacology (medical) 030212 general & internal medicine Longitudinal Studies Seroconversion Homosexuality Male education Past medical history education.field_of_study business.industry Antibody titer virus diseases 030104 developmental biology Infectious Diseases Cross-Sectional Studies Immunology Herpesvirus 8 Human HIV-1 business |
| Zdroj: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 23(4) |
| ISSN: | 1437-7780 |
| Popis: | High human herpesvirus 8 (HHV-8) seroprevalence has been reported in men who have sex with men (MSM) and are infected with HIV-1. However, it is unclear when they become infected with HHV-8. Thus, we conducted cross-sectional and longitudinal investigations of HHV-8 seroprevalence in HIV-1-infected individuals in Osaka, Japan.Plasma was collected from 121 individuals infected with HIV-1 and the anti-HHV-8 antibody titer was measured using an enzyme-linked immunosorbent assay with whole virus lysate. Subjects were classified into those with and without a past medical history of HHV-8-associated disease; the latter group was then classified into 3 subgroups based on the assumed route of HIV-1 infection: blood products, homosexual contact, and other routes. HHV-8 seroprevalence was compared among the groups and measured again approximately 3 years after the baseline measurement. The relationship between HHV-8 seropositivity and possible associated factors was also investigated.All 15 subjects with HHV-8-associated disease were seropositive, and all 11 subjects in the blood product group were seronegative. In the MSM group, 25 (30%) of 79 subjects were HHV-8 seropositive and, in the non-MSM group, 1 (6%) of 16 subjects was (p 0.0001). In the longitudinal investigation, seroconversion was observed in 10 (19%) of 52 subjects in the MSM group who were seronegative at baseline. A correlation was observed between seroconversion and symptomatic syphilis (p = 0.0432).HHV-8 seropositivity and seroconversion rates were high in HIV-1-infected MSM, suggesting that, currently, HHV-8 is an epidemic pathogen in this population. |
| Databáze: | OpenAIRE |
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