Analyses of the Local Control of Pulmonary Oligometastases after Stereotactic Body Radiotherapy and the Impact of Local Control on Survival
Autor: | Atsuro Terahara, Yuzuru Niibe, Kazunari Yamada, Keiichi Jingu, Yoshihiko Manabe, Hideomi Yamashita, Katsuya Yahara, Takaya Yamamoto, Ryoong Jin Oh, Kuniaki Katsui, Takashi Shintani, Masatoki Ozaki, Mitsuru Kobayashi, Masahiko Aoki, Hiroshi Onishi, Atsushi Nishikawa |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Adult Male Cancer Research medicine.medical_specialty Multivariate analysis Lung Neoplasms Adolescent Stereotactic body radiotherapy Metastasis-directed therapy Radiosurgery lcsh:RC254-282 Gastroenterology Effective dose (radiation) 03 medical and health sciences Young Adult 0302 clinical medicine Surgical oncology Internal medicine Pulmonary oligometastases Genetics medicine Humans Sync-oligometastases Survival analysis Aged Aged 80 and over Performance status business.industry Proportional hazards model Oligo-recurrence Retrospective cohort study Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Survival Analysis 030104 developmental biology Oncology Local control 030220 oncology & carcinogenesis Adenocarcinoma Female business Research Article |
Zdroj: | BMC Cancer BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020) |
DOI: | 10.21203/rs.3.rs-35650/v4 |
Popis: | Background Successful local therapy for oligometastases may lead to longer survival. The purpose of this multicentre retrospective study was to investigate factors affecting the local control (LC) of pulmonary oligometastases treated by stereotactic body radiotherapy (SBRT) and to investigate the impact of LC on survival. Methods The inclusion criteria included 1 to 5 metastases, the primary lesion and other extrathoracic metastases were controlled before SBRT, and the biological effective dose (BED10) of the SBRT was 75 Gy or more. The Cox proportional hazards model was used for analyses. Results Data of 1378 patients with 1547 tumours from 68 institutions were analysed. The median follow-up period was 24.2 months. The one-year, 3-year and 5-year LC rates were 92.1, 81.3 and 78.6%, respectively, and the 1-year, 3-year and 5-year overall survival rates were 90.1, 60.3 and 45.5%, respectively. Multivariate analysis for LC showed that increased maximum tumour diameter (p = 0.011), type A dose calculation algorithm (p = 0.005), shorter overall treatment time of SBRT (p = 0.035) and colorectal primary origin (p p p = 0.013; 2–3 vs. 0, p p = 0.038), squamous cell carcinoma (vs. adenocarcinoma, p = 0.006) and increased maximum tumour diameter (p Conclusions Several factors of oligometastases and SBRT affected LC. LC of pulmonary oligometastases by SBRT showed a significant survival benefit compared to patients with local failure. |
Databáze: | OpenAIRE |
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