MDM4 as a Prognostic Factor for Patients With Gastric Cancer With Low Expression of p53
| Autor: | Mitsuaki Hirose, Masashi Sato, Ichinosuke Hyodo, Mamiko Imanishi, Kenji Yamato, Akinori Sugaya, Xiaoxuan Wang, Toshikazu Moriwaki, Xiaochen Zhang, Shinji Endo, Yoshiyuki Yamamoto |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research Population Cell Cycle Proteins Drug resistance Disease-Free Survival Stomach Neoplasms Cell Line Tumor Proto-Oncogene Proteins Antineoplastic Combined Chemotherapy Protocols medicine Humans Cytotoxic T cell Stage (cooking) education Aged education.field_of_study biology business.industry Cancer Proto-Oncogene Proteins c-mdm2 General Medicine Middle Aged medicine.disease Immunohistochemistry Oxaliplatin Oncology Cell culture Multivariate Analysis biology.protein Cancer research Mdm2 Female Fluorouracil Cisplatin Tumor Suppressor Protein p53 business medicine.drug |
| Zdroj: | Anticancer Research. 41:1475-1483 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | Background/aim The oncoproteins murine double minute (MDM) 2 and MDM4 inactivate tumor-suppressor protein p53. Their mutual relationship with the prognosis of gastric cancer (GC) remains unknown. Patients and methods Expression of MDM2, MDM4, and p53 in tumors of 241 patients with GC were evaluated immunohistochemically. Effects of overexpression of MDM4 on tumor-growth properties and sensitivity to cytotoxic drugs were investigated using NUGC4 human GC cell line. Results High expression of p53 was associated with poor overall survival in the whole population. Among 173 patients with low expression of p53 (implying nonmutation), high expression of MDM4 was an independent factor of poor prognosis in both stage I-III and IV, but of MDM2 was not. MDM4-transduced NUGC4 cells formed twice as many colonies and had a higher 50% inhibitory concentration for 5-fluorouracil and oxaliplatin than did the control cells. Conclusion MDM4 expression is a factor conferring poor prognosis in patients with GC with low expression of p53 and may confer drug resistance. |
| Databáze: | OpenAIRE |
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