Limitations of metabolic activation systems used with in vitro tests for carcinogens
| Autor: | A. Dipple, J. E. Tomaszewski, C. A. H. Bigger, R. S. Lake |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Anthracene
Multidisciplinary 9 10-Dimethyl-1 2-benzanthracene Drug Evaluation Preclinical Deoxyribonucleosides DNA Biology In vitro Rats chemistry.chemical_compound Mice chemistry Biochemistry Liver Yield (chemistry) Benz(a)Anthracenes Carcinogens Microsomes Liver Animals Humans Carcinogen Cells Cultured Skin |
| Zdroj: | Science (New York, N.Y.). 209(4455) |
| ISSN: | 0036-8075 |
| Popis: | Important differences between the metabolic activation of 7,12-dimethylbenz[a]anthracene in intact cellular systems and in liver homogenates suggest that the use of homogenates in conjunction with short-term assays for carcinogens could yield misleading results. |
| Databáze: | OpenAIRE |
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