GLUT4 in the Endocrine Pancreas - Indicating an Impact in Pancreatic Islet Cell Physiology?
| Autor: | S Streck, Ina Bähr, Ivonne Bazwinsky-Wutschke, S. Wolgast, Elmar Peschke, Dirk Wedekind, K Hofmann, Eckhard Mühlbauer |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Adipose tissue Biochemistry Cell Line Diabetes Mellitus Experimental Islets of Langerhans Mice Endocrinology Western blot Antibody Specificity Internal medicine Diabetes mellitus medicine Animals Humans Insulin Endocrine system RNA Messenger Rats Wistar Aged Glucose Transporter Type 2 Glucose Transporter Type 4 medicine.diagnostic_test biology business.industry Biochemistry (medical) Glucose transporter General Medicine Middle Aged medicine.disease Rats Diabetes Mellitus Type 1 Glucose medicine.anatomical_structure Diabetes Mellitus Type 2 Gene Expression Regulation biology.protein Female Pancreas business hormones hormone substitutes and hormone antagonists GLUT4 |
| Zdroj: | Hormone and Metabolic Research. 44:442-450 |
| ISSN: | 1439-4286 0018-5043 |
| Popis: | The glucose transporter GLUT4 is well known to facilitate the transport of blood glucose into insulin-sensitive muscle and adipose tissue. In this study, molecular, immunohistochemical, and Western blot investigations revealed evidence that GLUT4 is also located in the mouse, rat, and human endocrine pancreas. In addition, high glucose decreased and insulin elevated the GLUT4 expression in pancreatic α-cells. In contrast, high glucose increased GLUT4 expression, whereas insulin led to a reduced expression level of the glucose transporter in pancreatic β-cells. In vivo experiments showed that in pancreatic tissue of type 2 diabetic rats as well as type 2 diabetic patients, the GLUT4 expression is significantly increased compared to the nondiabetic control group. Furthermore, type 1 diabetic rats exhibited reduced GLUT4 transcript levels in pancreatic tissue, whereas insulin treatment of type 1 diabetic animals enhanced the GLUT4 expression back to control levels. These data provide evidence for the existence of GLUT4 in the endocrine pancreas and indicate a physiological relevance of this glucose transporter as well as characteristic changes in diabetic disease. |
| Databáze: | OpenAIRE |
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