Ghrelin’s Relationship to Blood Glucose
| Autor: | Jeffrey M. Zigman, Bharath K. Mani, Kripa Shankar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
0301 basic medicine Food intake medicine.medical_specialty 030209 endocrinology & metabolism Endogeny Body weight Eating 03 medical and health sciences 0302 clinical medicine Endocrinology Diabetes mellitus Internal medicine Orexigenic medicine Animals Humans Obesity Adiposity Starvation business.industry Body Weight digestive oral and skin physiology Mini-Review medicine.disease Ghrelin 030104 developmental biology Hyperglycemia medicine.symptom Energy Metabolism business hormones hormone substitutes and hormone antagonists Ghrelin secretion medicine.drug |
| Zdroj: | Endocrinology. 160:1247-1261 |
| ISSN: | 1945-7170 |
| DOI: | 10.1210/en.2019-00074 |
| Popis: | Much effort has been directed at studying the orexigenic actions of administered ghrelin and the potential effects of the endogenous ghrelin system on food intake, food reward, body weight, adiposity, and energy expenditure. Although endogenous ghrelin’s actions on some of these processes remain ambiguous, its glucoregulatory actions have emerged as well-recognized features during extreme metabolic conditions. The blood glucose–raising actions of ghrelin are beneficial during starvation-like conditions, defending against life-threatening falls in blood glucose, but they are seemingly detrimental in obese states and in certain monogenic forms of diabetes, contributing to hyperglycemia. Also of interest, blood glucose negatively regulates ghrelin secretion. This article reviews the literature suggesting the existence of a blood glucose–ghrelin axis and highlights the factors that mediate the glucoregulatory actions of ghrelin, especially during metabolic extremes such as starvation and diabetes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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